Vaginal microbiome transplantation in women with intractable bacterial vaginosis

Ahinoam Lev-Sagie, Debra Goldman-Wohl, Yotam Cohen, Mally Dori-Bachash, Avner Leshem, Uria Mor, Jacob Strahilevitz, Allon E. Moses, Hagit Shapiro, Simcha Yagel, Eran Elinav

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

We report the results of a first exploratory study testing the use of vaginal microbiome transplantation (VMT) from healthy donors as a therapeutic alternative for patients suffering from symptomatic, intractable and recurrent bacterial vaginosis (ClinicalTrials.gov NCT02236429). In our case series, five patients were treated, and in four of them VMT was associated with full long-term remission until the end of follow-up at 5–21 months after VMT, defined as marked improvement of symptoms, Amsel criteria, microscopic vaginal fluid appearance and reconstitution of a Lactobacillus-dominated vaginal microbiome. One patient presented with incomplete remission in clinical and laboratory features. No adverse effects were observed in any of the five women. Notably, remission in three patients necessitated repeated VMT, including a donor change in one patient, to elicit a long-standing clinical response. The therapeutic efficacy of VMT in women with intractable and recurrent bacterial vaginosis should be further determined in randomized, placebo-controlled clinical trials.

שפה מקוריתאנגלית
עמודים (מ-עד)1500-1504
מספר עמודים5
כתב עתNature Medicine
כרך25
מספר גיליון10
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 אוק׳ 2019

ASJC Scopus subject areas

  • ???subjectarea.asjc.1300.1300???

טביעת אצבע

להלן מוצגים תחומי המחקר של הפרסום 'Vaginal microbiome transplantation in women with intractable bacterial vaginosis'. יחד הם יוצרים טביעת אצבע ייחודית.

פורמט ציטוט ביבליוגרפי