Tumor Growth Ameliorates Cardiac Dysfunction

Lama Awwad, Rona Shofti, Tali Haas, Ami Aronheim

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים


Heart failure and cancer are the deadliest diseases worldwide. Murine models for cardiac remodeling and heart failure demonstrate that cardiac dysfunction promotes cancer progression and metastasis spread. Yet, no information is available on whether and how tumor progression affects cardiac remodeling. Here, we examined cardiac remodeling following transverse aortic constriction (TAC) in the presence or absence of proliferating cancer cells. We show that tumor-bearing mice, of two different cancer cell lines, display reduced cardiac hypertrophy, lower fibrosis and improved cardiac contractile function following pressure overload induced by TAC surgery. Integrative analysis of qRT-PCR, flow cytometry and immunofluorescence identified tumor-dependent M1-to-M2 polarization in the cardiac macrophage population as a mediator of the beneficial tumor effect on the heart. Importantly, tumor-bearing mice lacking functional macrophages fail to improve cardiac function and display sustained fibrosis.

שפה מקוריתאנגלית
מספר המאמר1853
כתב עתCells
מספר גיליון14
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - יולי 2023

ASJC Scopus subject areas

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