Transforming parasites into their own foes: parasitic extracellular vesicles as a vaccine platform

Daniel Alfandari, Sharon Cadury, Mattia I. Morandi, Neta Regev-Rudzki

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Parasitic diseases continue to afflict millions of people globally. However, traditional vaccine development strategies are often difficult to apply to parasites, leaving an immense unmet need for new effective vaccines for the prevention and control of parasitic infections. As parasites commonly use extracellular vesicles (EVs) to interact with, interfere with, or modulate the host immune response from a distance, parasite-derived EVs may provide promising vaccine agents that induce immunity against parasitic infections. We here present achievements to date and the challenges and limitations associated with using parasitic EVs in a clinical context. Despite the many difficulties that need to be overcome, we believe this direction could offer a new and reliable source of therapeutics for various neglected parasitic diseases.

שפה מקוריתאנגלית
עמודים (מ-עד)913-928
מספר עמודים16
כתב עתTrends in Parasitology
כרך39
מספר גיליון11
תאריך מקוון מוקדם25 ספט׳ 2023
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - נוב׳ 2023

ASJC Scopus subject areas

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