The contribution of common rpsL mutations in Escherichia coli to sensitivity to ribosome targeting antibiotics

Gidi Pelchovich, Rachel Schreiber, Alina Zhuravlev, Uri Gophna

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Point mutations in the rpsL gene encoding ribosomal protein S12 can generate resistance to streptomycin, resulting in rapid emergence of resistance to this antibiotic during treatment. In this work, we demonstrate that while spontaneous rpsL mutants in Escherichia coli are resistant to streptomycin, they are more sensitive to the ribosome - targeting antibiotics chloramphenicol, tetracycline and erythromycin. Moreover, combinations of these antibiotics, even in low concentrations were enough to achieve complete growth inhibition of both wild type and rpsL mutant strains. Thus, combining ribosome-targeting drugs can be used as a new treatment strategy that may be effective against streptomycin-resistant ribosome mutants.

שפה מקוריתאנגלית
עמודים (מ-עד)558-562
מספר עמודים5
כתב עתInternational Journal of Medical Microbiology
כרך303
מספר גיליון8
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - דצמ׳ 2013

ASJC Scopus subject areas

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  • ???subjectarea.asjc.2700.2726???
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