Rapid Point-of-Care-Tests for Stroke Monitoring

Dorin Harpaz, Evgeni Eltzov, Raymond CS Seet, Robert S Marks, Alfred IY Tok

פרסום מחקרי: פרק בספר / בדוח / בכנספרקביקורת עמיתים

תקציר

Stroke contributes to at least 7 million deaths annually and is the second leading cause of death globally. Ischemic stroke is the most common type of stroke where an interruption of blood flow within brain tissues can lead to cessation of brain activities. Central to existing reperfusion treatment strategies is prompt restoration of blood supply to compromised brain tissues. Existing methods of monitoring the progress of stroke evolution are limited to clinical evaluation and neuroimaging techniques. With advances in biomarker research, there is now a growing interest in the use of stroke biomarkers to guide clinical decision-making, especially for on-site biomarker measurements, to make time-sensitive decisions on stroke prognosis. This chapter presents an overview on point-of-care-tests (POCT) used to guide stroke prognosis, with the aim of shortening time-to-treatment, classifying stroke subtypes and improving patient’s outcome. First, the current stroke monitoring workflow is presented, which highlights gaps for an improved bedside biomarker assessment. Second, a detailed overview on the different POCTs used for stroke monitoring is specified. Last, a novel approach for the creation of a future successful stroke POCT is presented, which combines the use of a quantitative and multiplex POCT for the detection of stroke-specific biomarkers.

שפה מקוריתאנגלית
כותר פרסום המארחOrganic Bioelectronics for Life Science and Healthcare
עורכיםAkio Yasuda, Wolfgang Knoll
מספר עמודים50
סטטוס פרסוםפורסם - 2019

סדרות פרסומים

שםMaterials Research Foundations
כרך56

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