NMR-fragment based virtual screening: A brief overview

Meenakshi Singh, Benjamin Tam, Barak Akabayov

פרסום מחקרי: פרסום בכתב עתסקירהביקורת עמיתים

תקציר

Fragment-based drug discovery (FBDD) using NMR has become a central approach over the last twenty years for development of small molecule inhibitors against biological macromolecules, to control a variety of cellular processes. Yet, several considerations should be taken into account for obtaining a therapeutically relevant agent. In this review, we aim to list the considerations that make NMR fragment screening a successful process for yielding potent inhibitors. Factors that may govern the competence of NMR in fragment based drug discovery are discussed, as well as later steps that involve optimization of hits obtained by NMR-FBDD.

שפה מקוריתאנגלית אמריקאית
מספר המאמר233
כתב עתMolecules
כרך23
מספר גיליון2
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 ינו׳ 2018

ASJC Scopus subject areas

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  • ???subjectarea.asjc.1600.1606???
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