Menaquinone and iron are essential for complex colony development in Bacillus subtilis

Gidi Pelchovich, Shira Omer-Bendori, Uri Gophna

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Cells of undomesticated species of Bacillus subtilis frequently form complex colonies during spreading on agar surfaces. Given that menaquinone is involved in another form of coordinated behavior, namely, sporulation, we looked for a possible role for menaquinone in complex colony development (CCD) in the B. subtilis strain NCIB 3610. Here we show that inhibition of menaquinone biosynthesis in B. subtilis indeed abolished its ability to develop complex colonies. Additionally some mutations of B. subtilis which confer defective CCD could be suppressed by menaquinone derivatives. Several such mutants mapped to the dhb operon encoding the genes responsible for the biosynthesis of the iron siderophore, bacillibactin. Our results demonstrate that both menaquinone and iron are essential for CCD in B. subtilis.

שפה מקוריתאנגלית
מספר המאמרe79488
כתב עתPLoS ONE
כרך8
מספר גיליון11
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 4 נוב׳ 2013

ASJC Scopus subject areas

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