Membrane insertion of—and membrane potential sensing by—semiconductor voltage nanosensors: Feasibility demonstration

Kyoungwon Park, Yung Kuo, Volodymyr Shvadchak, Antonino Ingargiola, Xinghong Dai, Lawrence Hsiung, Wookyeom Kim, Hong Zhou, Peng Zou, Alex J. Levine, Jack Li, Shimon Weiss

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.

שפה מקוריתאנגלית
מספר המאמרe1601453
כתב עתScience Advances
כרך4
מספר גיליון1
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - ינו׳ 2018
פורסם באופן חיצוניכן

ASJC Scopus subject areas

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