Manipulating fear associations via optogenetic modulation of amygdala inputs to prefrontal cortex

Oded Klavir, Matthias Prigge, Ayelet Sarel, Rony Paz, Ofer Yizhar

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Fear-related disorders are thought to reflect strong and persistent fear memories. The basolateral amygdala (BLA) and the medial prefrontal cortex (mPFC) form strong reciprocal synaptic connections that play a key role in acquisition and extinction of fear memories. While synaptic contacts of BLA cells onto mPFC neurons are likely to play a crucial role in this process, the BLA connects with several additional nuclei within the fear circuit that could relay fear-associated information to the mPFC, and the contribution of direct monosynaptic BLA–mPFC inputs is not yet clear. Here we establish an optogenetic stimulation protocol that induces synaptic depression in BLA–mPFC synapses. In behaving mice, optogenetic high-frequency stimulation of BLA inputs to mPFC interfered with retention of cued associations, attenuated previously acquired cue-associated responses in mPFC neurons and facilitated extinction. Our findings demonstrate the contribution of BLA inputs to mPFC in forming and maintaining cued fear associations.
שפה מקוריתאנגלית
עמודים (מ-עד)836-844
מספר עמודים9
כתב עתNature Neuroscience
כרך20
מספר גיליון6
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 יוני 2017

ASJC Scopus subject areas

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