Magic-angle spinning nmr of bacteriophage viruses

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Bacteriophages are viruses that infect bacteria. In their simplest form they are highly symmetric biomolecular assemblies that consist of an inner genomic core wrapped by a protein coat. More complex bacteriophages have capsid shells that include several proteins, some have short or long protein tails, as well as additional fibrous tail tube protein (TTP) attachments. Magic-angle spinning (MAS) solid-state NMR provides an opportunity to study these high-molecular-weight (tens of megadaltons) phage systems in great detail. This article focuses on several filamentous and icosahedral phages of various complexities, showing the hierarchy of information available by NMR – protein and deoxyribonucleic acid (DNA) chemical shifts; secondary, tertiary, and quaternary structures; hydration; protein–DNA interactions; and capsid dynamics.

שפה מקוריתאנגלית
עמודים (מ-עד)173-182
מספר עמודים10
כתב עתeMagRes
כרך9
מספר גיליון2
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 2020

ASJC Scopus subject areas

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טביעת אצבע

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