Lasting antibody responses are mediated by a combination of newly formed and established bone marrow plasma cells drawn from clonally distinct precursors

Irene Chernova, Derek D. Jones, Joel R. Wilmore, Alexandra Bortnick, Mesut Yucel, Uri Hershberg, David Allman

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Current models hold that serum Ab titers are maintained chiefly by long-lived bone marrow (BM) plasma cells (PCs). In this study, we characterize the role of subpopulations of BM PCs in long-Term humoral responses to T cell-dependent Ag. Surprisingly, our results indicate that 40-50% of BM PCs are recently formed cells, defined, in part, by rapid steady-state turnover kinetics and secretion of low-affinity IgM Abs. Further, for months after immunization with a hapten-protein conjugate, newly formed Aginduced, IgM-secreting BM PCs were detected in parallel with longer-lived IgG-secreting cells, suggesting ongoing and parallel input to the BM PC pool from two distinct pools of activated B cells. Consistent with this interpretation, IgM and IgG Abs secreted by cells within distinct PC subsets exhibited distinct L chain usage. We conclude that long-Term Ab responses are maintained by a dynamic BM PC pool composed of both recently formed and long-lived PCs drawn from clonally disparate precursors.

שפה מקוריתאנגלית אמריקאית
עמודים (מ-עד)4971-4979
מספר עמודים9
כתב עתJournal of Immunology
כרך193
מספר גיליון10
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 15 נוב׳ 2014
פורסם באופן חיצוניכן

ASJC Scopus subject areas

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  • ???subjectarea.asjc.2400.2403???

טביעת אצבע

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