Is it necessary to wait several minutes between applications of different topical ophthalmic solutions? A preliminary study with tropicamide eye drops in healthy dogs

Dikla Arad, Reut Deckel, Oren Pe’er, Maya Ross, Lionel Sebbag, Ron Ofri

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Objective: To evaluate the efficacy of topical tropicamide when placed at different time intervals before or after a saline drop. Animals studied: Eight healthy Labrador and golden retriever dogs. Procedures: The effect of 1% tropicamide on pupillary diameter (PD) was measured over 240 min when administered alone (control) and then 1 and 5 min prior to, or following, application of a saline drop, with 1-week washout between each of the five trials. Data were analyzed using repeated-measures ANOVA and Tukey post hoc test. Results: Only 6/110 pairwise comparisons among the 5 trials were statistically significant (p ≤.035), with post-hoc analysis showing no significant differences (p ≥.14) between the overall means of all trials. In all five trials, maximal PD was reached 30 min after tropicamide application and maintained until 210 min for 180 min (p =.0005). Conclusions: Our results suggest that waiting 1 min between applications of different ophthalmic solutions may be sufficient for maximal drug effect. Care should be taken when extrapolating these results to other species and different ophthalmic formulations.

שפה מקוריתאנגלית אמריקאית
עמודים (מ-עד)374-379
מספר עמודים6
כתב עתVeterinary Ophthalmology
כרך24
מספר גיליון4
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - יולי 2021

ASJC Scopus subject areas

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