Induction of diffuse axonal brain injury in rats based on rotational acceleration

Dmitry Frank, Israel Melamed, Benjamin F. Gruenbaum, Julia Grinshpun, Ruslan Kuts, Rachel Shvartsur, Abed N. Azab, Mohamad H. Assadi, Max Vinokur, Matthew Boyko

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים


Traumatic brain injury (TBI) is a major cause of death and disability. Diffuse axonal injury (DAI) is the predominant mechanism of injury in a large percentage of TBI patients requiring hospitalization. DAI involves widespread axonal damage from shaking, rotation or blast injury, leading to rapid axonal stretch injury and secondary axonal changes that are associated with a long-lasting impact on functional recovery. Historically, experimental models of DAI without focal injury have been difficult to design. Here we validate a simple, reproducible and reliable rodent model of DAI that causes widespread white matter damage without skull fractures or contusions.

שפה מקוריתאנגלית אמריקאית
מספר המאמרe61198
כתב עתJournal of Visualized Experiments
מספר גיליון159
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 מאי 2020

ASJC Scopus subject areas

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