Identification of legionella effectors using bioinformatic approaches

פרסום מחקרי: פרק בספר / בדוח / בכנספרקביקורת עמיתים


Legionella pneumophila the causative agent of Legionnaires' disease, actively manipulates host cell processes to establish a replication niche inside host cells. The establishment of its replication niche requires a functional Icm/Dot type IV secretion system which translocates about 300 effector proteins into host cells during infection. Many of these effectors were first identified as effector candidates by several bioinformatic approaches, and these predicted effectors were later examined experimentally for translocation and a large number of which were validated as effector proteins. Here, I summarized the bioinformatic approaches that were used to identify these effectors.

שפה מקוריתאנגלית
כותר פרסום המארחLegionella
כותר משנה של פרסום המארחMethods and Protocols
מספר עמודים8
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 2013

סדרות פרסומים

שםMethods in Molecular Biology

ASJC Scopus subject areas

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טביעת אצבע

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