Host succinate is an activation signal for Salmonella virulence during intracellular infection

Gili Rosenberg, Dror Yehezkel, Dotan Hoffman, Moran Fremder, Hadar Ben-Arosh, Leia Vainman, Noa Nissani, Shelly Hen-Avivi, Shirley Brenner, Maxim Itkin, Sergey Malitsky, Ehud Ohana, Noa Bossel Ben-Moshe, Roi Avraham

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Key to the success of intracellular pathogens is the ability to sense and respond to a changing host cell environment. Macrophages exposed to microbial products undergo metabolic changes that drive inflammatory responses. However, the role of macrophage metabolic reprogramming in bacterial adaptation to the intracellular environment has not been explored. Here, using metabolic profiling and dual RNA sequencing, we show that succinate accumulation in macrophages is sensed by intracellular Salmonella Typhimurium (S. Tm) to promote antimicrobial resistance and type III secretion. S. Tm lacking the succinate uptake transporter DcuB displays impaired survival in macrophages and in mice. Thus, S. Tm co-opts the metabolic reprogramming of infected macrophages as a signal that induces its own virulence and survival, providing an additional perspective on metabolic host-pathogen cross-talk.

שפה מקוריתאנגלית
עמודים (מ-עד)400-405
מספר עמודים6
כתב עתScience
כרך371
מספר גיליון6527
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 22 ינו׳ 2021

ASJC Scopus subject areas

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להלן מוצגים תחומי המחקר של הפרסום 'Host succinate is an activation signal for Salmonella virulence during intracellular infection'. יחד הם יוצרים טביעת אצבע ייחודית.

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