GABAergic Lateral Interactions Tune the Early Stages of Visual Processing in Drosophila

Limor Freifeld, Damon A. Clark, Mark J. Schnitzer, Mark A. Horowitz, Thomas R. Clandinin

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

Early stages of visual processing must capture complex, dynamic inputs. While peripheral neurons often implement efficient encoding by exploiting natural stimulus statistics, downstream neurons are specialized to extract behaviorally relevant features. How do these specializations ariseα We use two-photon imaging in Drosophila to characterize a first-order interneuron, L2, that provides input to a pathway specialized for detecting moving dark edges. GABAergic interactions, mediated in part presynaptically, create an antagonistic and anisotropic center-surround receptive field. This receptive field is spatiotemporally coupled, applying differential temporal processing to large and small dark objects, achieving significant specialization. GABAergic circuits also mediate OFF responses and balance these with responses to ON stimuli. Remarkably, the functional properties of L2 are strikingly similar to those of bipolar cells, yet emerge through different molecular and circuit mechanisms. Thus, evolution appears to have converged on a common strategy for processing visual information at the first synapse

שפה מקוריתאנגלית
עמודים (מ-עד)1075-1089
מספר עמודים15
כתב עתNeuron
כרך78
מספר גיליון6
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 19 יוני 2013
פורסם באופן חיצוניכן

ASJC Scopus subject areas

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