EGF receptor family: Twisting targets for improved cancer therapies

Antony W. Burgess, Yoav I. Henis, Nancy E. Hynes, Thomas Jovin, Alexander Levitzki, Ronit Pinkas-Kramarski, Yosef Yarden

פרסום מחקרי: פרסום בכתב עתמאמרביקורת עמיתים

תקציר

The epidermal growth factor receptor (EGFR) undergoes a conformational change in response to ligand binding. The ligand-induced changes in cell surface aggregation and mobility have a profound effect on the function of all the family members. Ligand also activates the EGFR intracellular kinase, stimulating proliferation and cell survival. The EGFR family are often activated, overexpressed or mutated in cancer cells and therapeutic drugs (including antibodies) can slow the progress of some cancers. This article provides a brief, annotated summary of the presentations and discussion which occurred at the Epidermal Growth Factor Receptor-Future Directions Conference held in Jerusalem in November 2013.

שפה מקוריתאנגלית
עמודים (מ-עד)74-81
מספר עמודים8
כתב עתGrowth Factors
כרך32
מספר גיליון2
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - אפר׳ 2014

ASJC Scopus subject areas

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