Chemical and semisynthesis of modified histones

Suman Kumar Maity, Muhammad Jbara, Ashraf Brik

פרסום מחקרי: פרסום בכתב עתסקירהביקורת עמיתים

תקציר

Post-translational modifications (PTMs) of histones play critical roles in the epigenetic regulation of eukaryotic genome by directly altering the biophysical properties of chromatin or by recruiting effector proteins. The large number of PTMs and the inherent complexity in their population and signaling processes make it highly challenging to understand epigenetics-related processes. To address these challenges, accesses to homogeneously modified histones are obligatory. Over the last decade, synthetic protein chemists have been devising novel synthetic tools and applying state-of-the-art chemoselective ligation strategies to prepare precious materials useful in answering fundamental questions in this area. In this short review, we cover some of the recent breakthroughs in these directions in particular the synthesis and semi-synthesis of modified histones and their use to unravel the mysteries of epigenetics.

שפה מקוריתאנגלית
עמודים (מ-עד)252-259
מספר עמודים8
כתב עתJournal of Peptide Science
כרך22
מספר גיליון5
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - 1 מאי 2016

ASJC Scopus subject areas

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