Can RNA Affect Memory Modulation? Implications for PTSD Understanding and Treatment

Tehila Cohen, Noam Shomron

פרסום מחקרי: פרסום בכתב עתסקירהביקורת עמיתים

תקציר

Memories are a central aspect of our lives, but the mechanisms underlying their formation, consolidation, retrieval, and extinction remain poorly understood. In this review, we explore the molecular mechanisms of memory modulation and investigate the effects of RNA on these processes. Specifically, we examine the effects of time and location on gene expression alterations. We then discuss the potential for harnessing these alterations to modulate memories, particularly fear memories, to alleviate post-traumatic stress disorder (PTSD) symptoms. The current state of research suggests that transcriptional changes play a major role in memory modulation and targeting them through microRNAs may hold promise as a novel approach for treating memory-related disorders such as PTSD.

שפה מקוריתאנגלית
מספר המאמר12908
כתב עתINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
כרך24
מספר גיליון16
מזהי עצם דיגיטלי (DOIs)
סטטוס פרסוםפורסם - אוג׳ 2023

ASJC Scopus subject areas

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