Zinc signaling (zinc’ing) in intestinal function

Michal Hershfinkel, Johnny Iv, Shannon L. Kelleher

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Zinc plays a well-documented role in intestinal function, perturbations in zinc homeostasis are associated with impaired barrier function and disease. A large repertoire of zinc transport proteins (ZnTs, ZIPs), TRP channels, and a distinct zinc receptor, ZnR/GPR39, are expressed along the intestinal epithelial cells. We will discuss the cellular roles of zinc ions, Zn2+, in activating signaling and physiological function of multiple cells along the intestinal epithelium. We will further describe the network of Zn2+-homeostatic proteins that are responsible for maintaining Zn2+ concentrations within the cytosol and their role in maintaining cellular functions. This review will reveal the tip of the iceberg that is currently known regarding the role of intestinal Zn2+ and will elucidate the need for extensive studies that will expound the complete map and physiological roles of Zn2+-homeostatic proteins.

Original languageAmerican English
Title of host publicationZinc Signaling
PublisherSpringer Singapore
Number of pages17
ISBN (Electronic)9789811505577
ISBN (Print)9789811505560
StatePublished - 1 Jan 2020


  • Barrier function
  • Intestine
  • Slc30a
  • Slc39a
  • Zinc
  • Zinc absorption
  • Zip
  • Znr/gpr39
  • Znt

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology
  • General Medicine


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