Z-DNA marks the spot for AIRE

Yael Goldfarb; Jakub Abramson

doi:10.1038/s41422-024-00964-x

Z-DNA marks the spot for AIRE

Yael Goldfarb
, Jakub Abramson

Department of Immunology and Regenerative Biology

Weizmann Institute of Science

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus, a step critical for the establishment of immunological tolerance to self. In their recent publication, Fang et al. provide novel mechanistic insights into AIRE’s modus operandi, by highlighting Z-DNA as a key cis-regulatory element, critical for guiding AIRE to its target genes.

Original language	English
Pages (from-to)	537-538
Number of pages	2
Journal	Cell Research
Volume	34
Issue number	8
Early online date	29 Apr 2024
DOIs	https://doi.org/10.1038/s41422-024-00964-x
State	Published - Aug 2024

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1038/s41422-024-00964-x

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title = "Z-DNA marks the spot for AIRE",

abstract = "Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus, a step critical for the establishment of immunological tolerance to self. In their recent publication, Fang et al. provide novel mechanistic insights into AIRE{\textquoteright}s modus operandi, by highlighting Z-DNA as a key cis-regulatory element, critical for guiding AIRE to its target genes.",

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AB - Autoimmune regulator (AIRE) is a unique transcriptional regulator that induces ectopic expression of thousands of tissue-specific genes in the thymus, a step critical for the establishment of immunological tolerance to self. In their recent publication, Fang et al. provide novel mechanistic insights into AIRE’s modus operandi, by highlighting Z-DNA as a key cis-regulatory element, critical for guiding AIRE to its target genes.

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JO - Cell Research

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Z-DNA marks the spot for AIRE

Abstract

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