WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh; Victoria L. Seewaldt; Rami I. Aqeilan

doi:10.4161/23723548.2014.965640

WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh
, Victoria L. Seewaldt
, Rami I. Aqeilan

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Comment/debate

Abstract

Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

Original language	English
Article number	e965640
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/23723548.2014.965640
State	Published - 3 Apr 2015

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

HIF1
WWOX
Warburg effect
aerobic glycolysis
breast cancer

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.4161/23723548.2014.965640

Cite this

@article{371742bb6d0346acb409ea259631831c,

title = "WWOX loss activates aerobic glycolysis",

abstract = "Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis{\textemdash}a state known as {\textquotedblleft}aerobic glycolysis.{\textquotedblright} Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.",

keywords = "HIF1, WWOX, Warburg effect, aerobic glycolysis, breast cancer",

author = "Muhannad Abu-Remaileh and Seewaldt, \{Victoria L.\} and Aqeilan, \{Rami I.\}",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor \& Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Muhannad Abu-Remaileh, Victoria L Seewaldt, and Rami I Aqeilan.",

year = "2015",

month = apr,

day = "3",

doi = "10.4161/23723548.2014.965640",

language = "English",

volume = "2",

journal = "Molecular and Cellular Oncology",

issn = "2372-3556",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - WWOX loss activates aerobic glycolysis

AU - Abu-Remaileh, Muhannad

AU - Seewaldt, Victoria L.

AU - Aqeilan, Rami I.

PY - 2015/4/3

Y1 - 2015/4/3

N2 - Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

AB - Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

KW - HIF1

KW - WWOX

KW - Warburg effect

KW - aerobic glycolysis

KW - breast cancer

UR - https://www.scopus.com/pages/publications/85046465766

U2 - 10.4161/23723548.2014.965640

DO - 10.4161/23723548.2014.965640

M3 - Comment/debate

SN - 2372-3556

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 2

M1 - e965640

ER -

WWOX loss activates aerobic glycolysis

Abstract

UN SDGs

Keywords

ASJC Scopus subject areas

Access to Document

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