WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh; Victoria L. Seewaldt; Rami I. Aqeilan

doi:https://doi.org/10.4161/23723548.2014.965640

WWOX loss activates aerobic glycolysis

Muhannad Abu-Remaileh, Victoria L. Seewaldt, Rami I. Aqeilan

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Comment/debate

Abstract

Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

Original language	English
Article number	e965640
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	2
DOIs	https://doi.org/10.4161/23723548.2014.965640
State	Published - 3 Apr 2015

Keywords

HIF1
WWOX
Warburg effect
aerobic glycolysis
breast cancer

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.4161/23723548.2014.965640

Cite this

@article{371742bb6d0346acb409ea259631831c,

title = "WWOX loss activates aerobic glycolysis",

abstract = "Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.",

keywords = "HIF1, WWOX, Warburg effect, aerobic glycolysis, breast cancer",

author = "Muhannad Abu-Remaileh and Seewaldt, {Victoria L.} and Aqeilan, {Rami I.}",

note = "Publisher Copyright: {\textcopyright} 2015, {\textcopyright} 2015 The Author(s). Published with license by Taylor & Francis Group, LLC. {\textcopyright} 2015, {\textcopyright} Muhannad Abu-Remaileh, Victoria L Seewaldt, and Rami I Aqeilan.",

year = "2015",

month = apr,

day = "3",

doi = "https://doi.org/10.4161/23723548.2014.965640",

language = "الإنجليزيّة",

volume = "2",

journal = "Molecular and Cellular Oncology",

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}

TY - JOUR

T1 - WWOX loss activates aerobic glycolysis

AU - Abu-Remaileh, Muhannad

AU - Seewaldt, Victoria L.

AU - Aqeilan, Rami I.

PY - 2015/4/3

Y1 - 2015/4/3

N2 - Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

AB - Cancer cells undergo reprogramming of glucose metabolism to limit energy production to glycolysis—a state known as “aerobic glycolysis.” Hypoxia-inducible factor 1 (HIF1α) is a transcription factor that regulates many genes responsible for this switch. As discussed here, new data suggest that the tumor suppressor WW domain-containing oxidoreductase (WWOX) modulates HIF1α, thereby regulating this metabolic state.

KW - HIF1

KW - WWOX

KW - Warburg effect

KW - aerobic glycolysis

KW - breast cancer

UR - http://www.scopus.com/inward/record.url?scp=85046465766&partnerID=8YFLogxK

U2 - https://doi.org/10.4161/23723548.2014.965640

DO - https://doi.org/10.4161/23723548.2014.965640

M3 - تعليقَ / نقاش

SN - 2372-3556

VL - 2

JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 2

M1 - e965640

ER -

WWOX loss activates aerobic glycolysis

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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