WWOX guards genome stability by activating ATM

Idit Hazan; Mohammad Abu-Odeh; Thomas G. Hofmann; Rami I. Aqeilan

doi:https://doi.org/10.1080/23723556.2015.1008288

WWOX guards genome stability by activating ATM

Idit Hazan, Mohammad Abu-Odeh, Thomas G. Hofmann, Rami I. Aqeilan

Department of Immunology and Cancer Research

The Hebrew University of Jerusalem

Research output: Contribution to journal › Comment/debate

Abstract

Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.

Original language	English
Article number	e1008288
Journal	Molecular and Cellular Oncology
Volume	2
Issue number	4
DOIs	https://doi.org/10.1080/23723556.2015.1008288
State	Published - 2 Oct 2015

All Science Journal Classification (ASJC) codes

Molecular Medicine
Cancer Research

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title = "WWOX guards genome stability by activating ATM",

abstract = "Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.",

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AU - Aqeilan, Rami I.

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N2 - Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.

AB - Common fragile sites (CFSs) tend to break upon replication stress and have been suggested to be “hot spots” for genomic instability. Recent evidence, however, implies that in the wake of DNA damage, WW domain-containing oxidoreductase (WWOX, the gene product of the FRA16D fragile site), associates with ataxia telangiectasia-mutated (ATM) and regulates its activation to maintain genomic integrity.

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DO - https://doi.org/10.1080/23723556.2015.1008288

M3 - تعليقَ / نقاش

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JO - Molecular and Cellular Oncology

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ER -

WWOX guards genome stability by activating ATM

Abstract

All Science Journal Classification (ASJC) codes

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