WW domain interactions regulate the Hippo tumor suppressor pathway

Z. Salah, R. I. Aqeilan

Research output: Contribution to journalReview articlepeer-review

Abstract

The Hippo kinase pathway is emerging as a conserved signaling pathway that is essential for organ growth and tumorigenesis in Drosophila and mammalians. Although the signaling of the core kinases is relatively well understood, less is known about the upstream inputs, downstream outputs and regulation of the whole cascade. Enrichment of the Hippo pathway components with WW domains and their cognate proline-rich interacting motifs provides a versatile platform for further understanding the mechanisms that regulate organ growth and tumorigenesis. Here, we review recently discovered mechanisms of WW domain-mediated interactions that contribute to the regulation of the Hippo signaling pathway in tumorigenesis. We further discuss new insights and future directions on the emerging role of such regulation.

Original languageEnglish
Article numbere172
JournalCell Death and Disease
Volume2
Issue number6
DOIs
StatePublished - Jun 2011

Keywords

  • Hippo pathway
  • ITCH
  • LATS1
  • Protein-protein interaction
  • WW domain

All Science Journal Classification (ASJC) codes

  • Cellular and Molecular Neuroscience
  • Cancer Research
  • Cell Biology
  • Immunology

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