What's hot about otoferlin

Research output: Contribution to journalComment/debate


Mutations in the otoferlin (OTOF) gene lead to profound hearing loss in humans. Interestingly, a number of missense otoferlin mutations cause hearing defects but only at higher body temperature, and the reasons for this have been elusive until now. A study published in this issue of The EMBO Journal (Strenzke et al,) adds insight into the underlying mechanisms for this heat-dependent hearing loss.

Original languageEnglish
Pages (from-to)2502-2504
Number of pages3
JournalEMBO Journal
Issue number23
StatePublished - 1 Dec 2016

All Science Journal Classification (ASJC) codes

  • General Immunology and Microbiology
  • General Biochemistry,Genetics and Molecular Biology
  • Molecular Biology
  • General Neuroscience


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