Voltage Sensors Embedded in G Protein-Coupled Receptors

Merav Tauber, Yair Ben-Chaim

Research output: Contribution to journalReview articlepeer-review

Abstract

Some signaling processes mediated by G protein-coupled receptors (GPCRs) are modulated by membrane potential. In recent years, increasing evidence that GPCRs are intrinsically voltage-dependent has accumulated. A recent publication challenged the view that voltage sensors are embedded in muscarinic receptors. Herein, we briefly discuss the evidence that supports the notion that GPCRs themselves are voltage-sensitive proteins and an alternative mechanism that suggests that voltage-gated sodium channels are the voltage-sensing molecules involved in such processes.

Original languageEnglish
JournalINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume25
Issue number10
DOIs
StatePublished - 13 May 2024

Keywords

  • G protein coupled receptors
  • muscarinic receptor
  • voltage dependence
  • voltage sensor

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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