@inbook{f1bc9fa7f7b94b82a07b5c1a207384b8,
title = "Visualization, Fate Mapping, Ablation, and Mutagenesis of Microglia in the Mouse Brain",
abstract = "Since the classical studies of P{\'i}o del R{\'i}o-Hortega, microglia research has come a long way. In particular, recent advances in bulk and single-cell (sc) transcriptomics have yielded many fascinating new insights into these intriguing immune cells at the interface with the central nervous system (CNS), both in small animal models and human samples. In parallel, tools developed by advanced mouse genetics have revealed the unique ontogeny of microglia and their striking dynamic interactions with other cells in the brain parenchyma. In this chapter, we will discuss various applications of the Cre/loxP-based approach that have enabled the study of microglia in their physiological context of the mouse brain. We will highlight selected key findings that have shaped our current understanding of these cells and discuss the technical intricacies of the Cre/loxP approach and some remaining challenges.",
author = "Kim, {Jung Seok} and Steffen Jung",
note = "Publisher Copyright: {\textcopyright} 2024. The Author(s), under exclusive license to Springer Nature Switzerland AG.",
year = "2024",
month = aug,
day = "30",
doi = "10.1007/978-3-031-55529-9_4",
language = "الإنجليزيّة",
isbn = "978-3-031-55528-2",
volume = "37",
series = "Advances in neurobiology",
publisher = "Springer",
pages = "53--63",
editor = "Marie-{\`E}ve Tremblay and Alexei Verkhratsky",
booktitle = "Microglia",
address = "ألمانيا",
}