@article{a05fe19a5890423d9ee528beab6ef0de,
title = "Visual Stimulation Switches the Polarity of Excitatory Input to Starburst Amacrine Cells",
abstract = "Direction-selective ganglion cells (DSGCs) are tuned to motion in one direction. Starburst amacrine cells (SACs) are thought to mediate this direction selectivity through precise anatomical wiring to DSGCs. Nevertheless, we previously found that visual adaptation can reverse DSGCs's directional tuning, overcoming the circuit anatomy. Here we explore the role of SACs in the generation and adaptation of direction selectivity. First, using pharmacogenetics and two photon calcium imaging, we validate that SACs are necessary for direction selectivity. Next, we demonstrate that exposure to an adaptive stimulus dramatically alters SACs' synaptic inputs. Specifically, after visual adaptation, On-SACs lose their excitatory input during light onset but gain an excitatory input during light offset. Our data suggest that visual stimulation alters the interactions between rod-and cone-mediated inputs that converge on the terminals of On-cone BCs. These results demonstrate how the sensory environment can modify computations performed by anatomically defined neuronal circuits.",
author = "Vlasits, {Anna L.} and Remi Bos and Morrie, {Ryan D.} and Cecile Fortuny and Flannery, {John G.} and Feller, {Marla B.} and Michal Rivlin-Etzion",
note = "National Science Foundation Graduate Research Fellowship Program [DGE 1106400]; NIH/NEI [1R01EY022975]; Foundation Fighting Blindness, USA; Human Frontier Science Program Organization; National Postdoctoral Award Program for Advancing Women in Science; National Institutes of Health NRSA [T32 GM 007232]; [NIH RO1EY019498]; [RO1EY013528]; [P30EY003176]We thank Scott Sternson (Janelia Farms) for the generous gift of PSEM ligand. This work was supported by grants NIH RO1EY019498, RO1EY013528, and P30EY003176. A.L.V. was supported by the National Science Foundation Graduate Research Fellowship Program under Grant No. DGE 1106400; C.F. and J.G.F. were supported by NIH/NEI 1R01EY022975 and the Foundation Fighting Blindness, USA; M.R.-E. was supported by the Human Frontier Science Program Organization and the National Postdoctoral Award Program for Advancing Women in Science; R.D.M was supported by a National Institutes of Health NRSA Trainee appointment on grant number T32 GM 007232.",
year = "2014",
month = sep,
doi = "https://doi.org/10.1016/j.neuron.2014.07.037",
language = "الإنجليزيّة",
volume = "83",
pages = "1172--1184",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "5",
}