Visceral Adipose Tissue E2F1-miRNA206/210 Pathway Associates with Type 2 Diabetes in Humans with Extreme Obesity

Nitzan Maixner; Yulia Haim; Matthias Blüher; Vered Chalifa-Caspi; Isana Veksler-Lublinsky; Nataly Makarenkov; Uri Yoel; Nava Bashan; Idit F. Liberty; Ivan Kukeev; Oleg Dukhno; Dan Levy; Assaf Rudich

doi:10.3390/cells11193046

Visceral Adipose Tissue E2F1-miRNA206/210 Pathway Associates with Type 2 Diabetes in Humans with Extreme Obesity

Nitzan Maixner, Yulia Haim, Matthias Blüher, Vered Chalifa-Caspi, Isana Veksler-Lublinsky, Nataly Makarenkov, Uri Yoel, Nava Bashan, Idit F. Liberty, Ivan Kukeev, Oleg Dukhno, Dan Levy, Assaf Rudich

Ben-Gurion University of the Negev

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elevated VAT-E2F1 in obesity is associated with VAT-miRNA alterations similar to, or distinct from, those described in cancer. Furthermore, we assessed if E2F1-associated miRNA changes may contribute to the link between high- VAT-E2F1 and a dysmetabolic obesity phenotype. Methods: We assembled a cohort of patients with obesity and high-VAT-E2F1, matched by age, sex, ±BMI to patients with low-VAT-E2F1, with and without obesity (8 patients/groupX3 groups).

Original language	American English
Article number	3046
Journal	Cells
Volume	11
Issue number	19
DOIs	https://doi.org/10.3390/cells11193046
State	Published - 1 Oct 2022

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

E2F1
dys-glycemia
miR-206
miR-210-5p
obesity

All Science Journal Classification (ASJC) codes

General Biochemistry,Genetics and Molecular Biology

Access to Document

10.3390/cells11193046

Cite this

@article{ca45d63ec2b64450b59c5e427407d854,

title = "Visceral Adipose Tissue E2F1-miRNA206/210 Pathway Associates with Type 2 Diabetes in Humans with Extreme Obesity",

abstract = "Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elevated VAT-E2F1 in obesity is associated with VAT-miRNA alterations similar to, or distinct from, those described in cancer. Furthermore, we assessed if E2F1-associated miRNA changes may contribute to the link between high- VAT-E2F1 and a dysmetabolic obesity phenotype. Methods: We assembled a cohort of patients with obesity and high-VAT-E2F1, matched by age, sex, ±BMI to patients with low-VAT-E2F1, with and without obesity (8 patients/groupX3 groups).",

keywords = "E2F1, dys-glycemia, miR-206, miR-210-5p, obesity",

author = "Nitzan Maixner and Yulia Haim and Matthias Bl{\"u}her and Vered Chalifa-Caspi and Isana Veksler-Lublinsky and Nataly Makarenkov and Uri Yoel and Nava Bashan and Liberty, \{Idit F.\} and Ivan Kukeev and Oleg Dukhno and Dan Levy and Assaf Rudich",

note = "Publisher Copyright: {\textcopyright} 2022 by the authors.",

year = "2022",

month = oct,

day = "1",

doi = "10.3390/cells11193046",

language = "American English",

volume = "11",

journal = "Cells",

issn = "2073-4409",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "19",

}

TY - JOUR

T1 - Visceral Adipose Tissue E2F1-miRNA206/210 Pathway Associates with Type 2 Diabetes in Humans with Extreme Obesity

AU - Maixner, Nitzan

AU - Haim, Yulia

AU - Blüher, Matthias

AU - Chalifa-Caspi, Vered

AU - Veksler-Lublinsky, Isana

AU - Makarenkov, Nataly

AU - Yoel, Uri

AU - Bashan, Nava

AU - Liberty, Idit F.

AU - Kukeev, Ivan

AU - Dukhno, Oleg

AU - Levy, Dan

AU - Rudich, Assaf

PY - 2022/10/1

Y1 - 2022/10/1

N2 - Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elevated VAT-E2F1 in obesity is associated with VAT-miRNA alterations similar to, or distinct from, those described in cancer. Furthermore, we assessed if E2F1-associated miRNA changes may contribute to the link between high- VAT-E2F1 and a dysmetabolic obesity phenotype. Methods: We assembled a cohort of patients with obesity and high-VAT-E2F1, matched by age, sex, ±BMI to patients with low-VAT-E2F1, with and without obesity (8 patients/groupX3 groups).

AB - Objective: Up-regulated expression of transcription-factor E2F1 in human visceral adipose tissue (VAT) characterizes a dysmetabolic obesity sub-phenotype. An E2F1-miRNA network has been described in multiple cancers. Here we investigated whether elevated VAT-E2F1 in obesity is associated with VAT-miRNA alterations similar to, or distinct from, those described in cancer. Furthermore, we assessed if E2F1-associated miRNA changes may contribute to the link between high- VAT-E2F1 and a dysmetabolic obesity phenotype. Methods: We assembled a cohort of patients with obesity and high-VAT-E2F1, matched by age, sex, ±BMI to patients with low-VAT-E2F1, with and without obesity (8 patients/groupX3 groups).

KW - E2F1

KW - dys-glycemia

KW - miR-206

KW - miR-210-5p

KW - obesity

UR - http://www.scopus.com/inward/record.url?scp=85139766507&partnerID=8YFLogxK

U2 - 10.3390/cells11193046

DO - 10.3390/cells11193046

M3 - Article

C2 - 36231008

SN - 2073-4409

VL - 11

JO - Cells

JF - Cells

IS - 19

M1 - 3046

ER -

Visceral Adipose Tissue E2F1-miRNA206/210 Pathway Associates with Type 2 Diabetes in Humans with Extreme Obesity

Abstract

UN SDGs

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this