Vibrio cholerae autoinducer CAI-1 interferes with pseudomonas aeruginosa quorum sensing and inhibits its growth

Hadas Ganin; Yael Danin-Poleg; Yechezkel Kashi; Michael M. Meijler

doi:10.1021/cb2004675

Vibrio cholerae autoinducer CAI-1 interferes with pseudomonas aeruginosa quorum sensing and inhibits its growth

Hadas Ganin, Yael Danin-Poleg, Yechezkel Kashi, Michael M. Meijler

Ben-Gurion University of the Negev, Technion - Israel Institute of Technology

Research output: Contribution to journal › Review article › peer-review

Abstract

The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.

Original language	American English
Pages (from-to)	659-665
Number of pages	7
Journal	ACS Chemical Biology
Volume	7
Issue number	4
DOIs	https://doi.org/10.1021/cb2004675
State	Published - 20 Apr 2012

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Molecular Medicine
Biochemistry

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10.1021/cb2004675

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title = "Vibrio cholerae autoinducer CAI-1 interferes with pseudomonas aeruginosa quorum sensing and inhibits its growth",

abstract = "The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.",

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AU - Kashi, Yechezkel

AU - Meijler, Michael M.

PY - 2012/4/20

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N2 - The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.

AB - The human pathogen Vibrio cholerae uses several small molecules to coordinate gene expression in a process termed quorum sensing (QS), and its main autoinducer is CAI-1. We have examined the activity of this signaling molecule in three other species of bacteria. Interestingly, while showing an inhibitory effect on QS in the opportunistic pathogen P. aeruginosa at low micromolar concentrations, it caused also growth inhibition at higher concentrations. In contrast, the two other bacteria were unaffected, and we suggest a possible mechanism for these effects, based on membrane perturbation studies.

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Vibrio cholerae autoinducer CAI-1 interferes with pseudomonas aeruginosa quorum sensing and inhibits its growth

Abstract

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