Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence

Amir Ben Tov; Shlomi Cohen; Raanan Shamir; Gabriel Chodick; Cheli Melzer-Cohen; Varda Shalev; Rochelle Fayngor; Yael Weintraub; Anat Yerushalmy-Feler; Jacob Kuint

doi:10.1097/MPG.0000000000002624

Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence

Amir Ben Tov, Shlomi Cohen, Raanan Shamir, Gabriel Chodick, Cheli Melzer-Cohen, Varda Shalev, Rochelle Fayngor, Yael Weintraub, Anat Yerushalmy-Feler, Jacob Kuint

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real-world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000 and 2012 and their matched controls. At a median of 12 years, VLBW prematurity was negatively associated with later development of CDA with a cumulative prevalence of 5.9 per 1000 versus 10.3 per 1000 (P=0.02), though more former VLBW premature infants were ever tested for CDA (48.5% vs 37.4%, P<0.001). The odds ratio for developing CDA among children born preterm at VLBW was 0.57 (95% confidence interval (CI) 0.35-0.92) as compared with matched controls. There was no difference in clinical characteristics of CDA between both groups. In conclusion, VLBW preterm infants present a decreased risk for the development of CDA during childhood and adolescence.

Original language	English
Pages (from-to)	478-481
Number of pages	4
Journal	Journal of Pediatric Gastroenterology and Nutrition
Volume	70
Issue number	4
DOIs	https://doi.org/10.1097/MPG.0000000000002624
State	Published - 1 Apr 2020

Keywords

celiac disease autoimmunity
prematurity
very low birth weight

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health
Gastroenterology

Access to Document

10.1097/MPG.0000000000002624

Cite this

Ben Tov, A., Cohen, S., Shamir, R., Chodick, G., Melzer-Cohen, C., Shalev, V., Fayngor, R., Weintraub, Y., Yerushalmy-Feler, A., & Kuint, J. (2020). Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence. Journal of Pediatric Gastroenterology and Nutrition, 70(4), 478-481. https://doi.org/10.1097/MPG.0000000000002624

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abstract = "Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real-world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000 and 2012 and their matched controls. At a median of 12 years, VLBW prematurity was negatively associated with later development of CDA with a cumulative prevalence of 5.9 per 1000 versus 10.3 per 1000 (P=0.02), though more former VLBW premature infants were ever tested for CDA (48.5\% vs 37.4\%, P<0.001). The odds ratio for developing CDA among children born preterm at VLBW was 0.57 (95\% confidence interval (CI) 0.35-0.92) as compared with matched controls. There was no difference in clinical characteristics of CDA between both groups. In conclusion, VLBW preterm infants present a decreased risk for the development of CDA during childhood and adolescence.",

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Ben Tov, A, Cohen, S, Shamir, R, Chodick, G, Melzer-Cohen, C, Shalev, V, Fayngor, R, Weintraub, Y, Yerushalmy-Feler, A & Kuint, J 2020, 'Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence', Journal of Pediatric Gastroenterology and Nutrition, vol. 70, no. 4, pp. 478-481. https://doi.org/10.1097/MPG.0000000000002624

TY - JOUR

T1 - Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence

AU - Ben Tov, Amir

AU - Cohen, Shlomi

AU - Shamir, Raanan

AU - Chodick, Gabriel

AU - Melzer-Cohen, Cheli

AU - Shalev, Varda

AU - Fayngor, Rochelle

AU - Weintraub, Yael

AU - Yerushalmy-Feler, Anat

AU - Kuint, Jacob

PY - 2020/4/1

Y1 - 2020/4/1

N2 - Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real-world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000 and 2012 and their matched controls. At a median of 12 years, VLBW prematurity was negatively associated with later development of CDA with a cumulative prevalence of 5.9 per 1000 versus 10.3 per 1000 (P=0.02), though more former VLBW premature infants were ever tested for CDA (48.5% vs 37.4%, P<0.001). The odds ratio for developing CDA among children born preterm at VLBW was 0.57 (95% confidence interval (CI) 0.35-0.92) as compared with matched controls. There was no difference in clinical characteristics of CDA between both groups. In conclusion, VLBW preterm infants present a decreased risk for the development of CDA during childhood and adolescence.

AB - Little is known about the effect of prematurity on later development of celiac disease (CD). We conducted a retrospective analysis of real-world data examining the association between very low birth weight (VLBW) prematurity and later development of CD autoimmunity (CDA) in 3580 infants born between years 2000 and 2012 and their matched controls. At a median of 12 years, VLBW prematurity was negatively associated with later development of CDA with a cumulative prevalence of 5.9 per 1000 versus 10.3 per 1000 (P=0.02), though more former VLBW premature infants were ever tested for CDA (48.5% vs 37.4%, P<0.001). The odds ratio for developing CDA among children born preterm at VLBW was 0.57 (95% confidence interval (CI) 0.35-0.92) as compared with matched controls. There was no difference in clinical characteristics of CDA between both groups. In conclusion, VLBW preterm infants present a decreased risk for the development of CDA during childhood and adolescence.

KW - celiac disease autoimmunity

KW - prematurity

KW - very low birth weight

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DO - 10.1097/MPG.0000000000002624

M3 - مقالة

C2 - 31961341

SN - 0277-2116

VL - 70

SP - 478

EP - 481

JO - Journal of Pediatric Gastroenterology and Nutrition

JF - Journal of Pediatric Gastroenterology and Nutrition

IS - 4

ER -

Very Low Birth Weight Preterm Infants have Decreased Celiac Disease Autoimmunity During Childhood and Adolescence

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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