TY - JOUR
T1 - Vectorial representation of spatial goals in the hippocampus of bats
AU - Sarel, Ayelet
AU - Finkelstein, Arseny
AU - Las, Liora
AU - Ulanovsky, Nachum
N1 - European Research Council; Israel Science Foundation [ISF 1319/13]; Minerva Foundation We thank S. Romani, A. Treves, A. Rubin, T. Stolero, D. Omer, T. Eliav, G. Ginosar, D. Blum, and S. Maimon for comments on the manuscript; O. Gobi and S. Kaufman for bat training; A. Tuval for veterinary support; C. Ra'anan and R. Eilam for histology; B. Pasmantirer and G. Ankaoua for mechanical designs; and G. Brodsky and H. Avital for graphics. This study was supported by research grants to N.U. from the European Research Council (ERC-StG NEUROBAT and ERC-CoG NATURAL_BAT_NAV), the Israel Science Foundation (ISF 1319/13), and the Minerva Foundation. Equipment support was provided by the Krenter Institute at the Weizmann Institute of Science. The data are archived on the Weizmann Institute of Science servers and will be made available on request. The results reported in this study were presented earlier in abstract form (31).
PY - 2017/1/13
Y1 - 2017/1/13
N2 - To navigate, animals need to represent not only their own position and orientation, but also the location of their goal. Neural representations of an animal's own position and orientation have been extensively studied. However, it is unknown how navigational goals are encoded in the brain.We recorded from hippocampal CA1 neurons of bats flying in complex trajectories toward a spatial goal.We discovered a subpopulation of neurons with angular tuning to the goal direction. Many of these neurons were tuned to an occluded goal, suggesting that goal-direction representation is memory-based. We also found cells that encoded the distance to the goal, often in conjunction with goal direction. The goaldirection and goal-distance signals make up a vectorial representation of spatial goals, suggesting a previously unrecognized neuronal mechanism for goal-directed navigation.
AB - To navigate, animals need to represent not only their own position and orientation, but also the location of their goal. Neural representations of an animal's own position and orientation have been extensively studied. However, it is unknown how navigational goals are encoded in the brain.We recorded from hippocampal CA1 neurons of bats flying in complex trajectories toward a spatial goal.We discovered a subpopulation of neurons with angular tuning to the goal direction. Many of these neurons were tuned to an occluded goal, suggesting that goal-direction representation is memory-based. We also found cells that encoded the distance to the goal, often in conjunction with goal direction. The goaldirection and goal-distance signals make up a vectorial representation of spatial goals, suggesting a previously unrecognized neuronal mechanism for goal-directed navigation.
UR - https://harvester-2-eu.services.rm.elsevier.com/ws/6ced8d3b-d9ff-4f31-979a-0647230ba9f4/1815c317-615c-4123-822c-c2c538e6ff99/ws/files/155780635/nu_Sci_VectorialRepresentationOfSpatial_AM2017.pdf
UR - http://www.scopus.com/inward/record.url?scp=85009743383&partnerID=8YFLogxK
U2 - https://doi.org/10.1126/science.aak9589
DO - https://doi.org/10.1126/science.aak9589
M3 - مقالة
C2 - 28082589
SN - 0036-8075
VL - 355
JO - Science
JF - Science
IS - 6321
M1 - 6321
ER -