Vagal nerve activity as a moderator of brain-immune relationships

Hideki Ohira; Masahiro Matsunaga; Takahiro Osumi; Seisuke Fukuyama; Jun Shinoda; Jitsuhiro Yamada; Yori Gidron

doi:https://doi.org/10.1016/j.jneuroim.2013.04.011

Vagal nerve activity as a moderator of brain-immune relationships

Hideki Ohira, Masahiro Matsunaga, Takahiro Osumi, Seisuke Fukuyama, Jun Shinoda, Jitsuhiro Yamada, Yori Gidron

Research output: Contribution to journal › Article › peer-review

Abstract

We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity.

Original language	American English
Pages (from-to)	28-36
Number of pages	9
Journal	Journal of Neuroimmunology
Volume	260
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.04.011
State	Published - 15 May 2013
Externally published	Yes

Keywords

Heart rate variability
Natural killer cells
Neuroimmunomodulation
Positron emission tomography
Vagus nerve

All Science Journal Classification (ASJC) codes

Clinical Neurology
Neurology
Immunology and Allergy
Immunology

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https://doi.org/10.1016/j.jneuroim.2013.04.011

Cite this

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title = "Vagal nerve activity as a moderator of brain-immune relationships",

abstract = "We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity.",

keywords = "Heart rate variability, Natural killer cells, Neuroimmunomodulation, Positron emission tomography, Vagus nerve",

author = "Hideki Ohira and Masahiro Matsunaga and Takahiro Osumi and Seisuke Fukuyama and Jun Shinoda and Jitsuhiro Yamada and Yori Gidron",

note = "Funding Information: This study was supported by a Health and Labor Sciences Research Grant on Research on Occupational Safety and Health from the Japan Ministry of Health, Labour, and Welfare (no. H17-RODO-5 ), and a Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) 2010 (no. 4102-21119003 ) from the Ministry of Education, Culture, Sports, Science and Technology, Japan . The authors thank Dr. Tokiko Isowa, Ms. Naho Ichikawa, Dr. Kenta Kimura, Dr. Makoto Miyakoshi, Dr. Noriaki Kanayama, and Dr. Hiroki Murakami for technical supports.",

year = "2013",

month = may,

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doi = "https://doi.org/10.1016/j.jneuroim.2013.04.011",

language = "American English",

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AU - Ohira, Hideki

AU - Matsunaga, Masahiro

AU - Osumi, Takahiro

AU - Fukuyama, Seisuke

AU - Shinoda, Jun

AU - Yamada, Jitsuhiro

AU - Gidron, Yori

N1 - Funding Information: This study was supported by a Health and Labor Sciences Research Grant on Research on Occupational Safety and Health from the Japan Ministry of Health, Labour, and Welfare (no. H17-RODO-5 ), and a Grant-in-Aid for Scientific Research on Innovative Areas (Research in a Proposed Research Area) 2010 (no. 4102-21119003 ) from the Ministry of Education, Culture, Sports, Science and Technology, Japan . The authors thank Dr. Tokiko Isowa, Ms. Naho Ichikawa, Dr. Kenta Kimura, Dr. Makoto Miyakoshi, Dr. Noriaki Kanayama, and Dr. Hiroki Murakami for technical supports.

PY - 2013/5/15

Y1 - 2013/5/15

N2 - We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity.

AB - We investigated whether vagal tone, as assessed by heart rate variability (HRV), moderates the neural correlates of immune and physiological responses to acute stress. Participants with low and high baseline HRV underwent a reversal learning task as an acute stressor. Natural killer cells, norepinephrine, and adrenocorticotropic hormone in peripheral blood changed with acute stress in the high HRV group only. Activity in the prefrontal cortex and striatum correlated with the immune and physiological indices in the high HRV group. High vagal tone may reflect more flexible top-down brain regulation of immune and physiological activity.

KW - Heart rate variability

KW - Natural killer cells

KW - Neuroimmunomodulation

KW - Positron emission tomography

KW - Vagus nerve

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IS - 1-2

ER -

Vagal nerve activity as a moderator of brain-immune relationships

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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