Abstract
Aim: To elucidate the interactions, uptake mechanisms and cytotoxicity profile of glucose-functionalized gold nanoparticles (2GF-GNPs), for expanding and advancing the recently proposed technology of metabolic-based cancer detection to a variety of cancer diseases. Methods: Several cell types with different metabolic features were used to assess the involvement of GLUT-1 and different endocytosis pathways in 2GF-GNP uptake, and the cytotoxicity profile of 2GF-GNPs. Results: Cellular uptake of 2GF-GNP strongly correlated with GLUT-1 surface expression, and occurred mainly through clathrin-mediated endocytosis. 2GF-GNPs showed no toxic effect on cell cycle and proliferation. Conclusion: These findings promote development of metabolic-based cancer detection technologies, and suggest that 2GF-GNPs may enable specific cancer detection in a wide range of tumors characterized by high GLUT-1 expression.
| Original language | English |
|---|---|
| Pages (from-to) | 1535-1549 |
| Number of pages | 15 |
| Journal | Nanomedicine |
| Volume | 13 |
| Issue number | 13 |
| DOIs | |
| State | Published - 2018 |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
Keywords
- GLUT-1
- cancer
- clathrin-mediated endocytosis
- glucose-coated nanoparticles
- gold nanoparticles
- metabolic-Targeting
ASJC Scopus subject areas
- Bioengineering
- Biomedical Engineering
- General Materials Science
- Medicine (miscellaneous)
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