Uptake mechanism of metabolic-Targeted gold nanoparticles

Tamar Dreifuss; Tal Shachar Ben-Gal; Katerina Shamalov; Aryeh Weiss; Avi Jacob; Tamar Sadan; Menachem Motiei; Rachela Popovtzer

doi:https://doi.org/10.2217/nnm-2018-0022

Uptake mechanism of metabolic-Targeted gold nanoparticles

Tamar Dreifuss, Tal Shachar Ben-Gal, Katerina Shamalov, Aryeh Weiss, Avi Jacob, Tamar Sadan, Menachem Motiei, Rachela Popovtzer

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Aim: To elucidate the interactions, uptake mechanisms and cytotoxicity profile of glucose-functionalized gold nanoparticles (2GF-GNPs), for expanding and advancing the recently proposed technology of metabolic-based cancer detection to a variety of cancer diseases. Methods: Several cell types with different metabolic features were used to assess the involvement of GLUT-1 and different endocytosis pathways in 2GF-GNP uptake, and the cytotoxicity profile of 2GF-GNPs. Results: Cellular uptake of 2GF-GNP strongly correlated with GLUT-1 surface expression, and occurred mainly through clathrin-mediated endocytosis. 2GF-GNPs showed no toxic effect on cell cycle and proliferation. Conclusion: These findings promote development of metabolic-based cancer detection technologies, and suggest that 2GF-GNPs may enable specific cancer detection in a wide range of tumors characterized by high GLUT-1 expression.

Original language	English
Pages (from-to)	1535-1549
Number of pages	15
Journal	Nanomedicine
Volume	13
Issue number	13
DOIs	https://doi.org/10.2217/nnm-2018-0022
State	Published - 2018

Keywords

GLUT-1
cancer
clathrin-mediated endocytosis
glucose-coated nanoparticles
gold nanoparticles
metabolic-Targeting

All Science Journal Classification (ASJC) codes

Bioengineering
Biomedical Engineering
General Materials Science
Medicine (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.2217/nnm-2018-0022

Cite this

@article{62c2f67d83184481997da13ac7875dd3,

title = "Uptake mechanism of metabolic-Targeted gold nanoparticles",

abstract = "Aim: To elucidate the interactions, uptake mechanisms and cytotoxicity profile of glucose-functionalized gold nanoparticles (2GF-GNPs), for expanding and advancing the recently proposed technology of metabolic-based cancer detection to a variety of cancer diseases. Methods: Several cell types with different metabolic features were used to assess the involvement of GLUT-1 and different endocytosis pathways in 2GF-GNP uptake, and the cytotoxicity profile of 2GF-GNPs. Results: Cellular uptake of 2GF-GNP strongly correlated with GLUT-1 surface expression, and occurred mainly through clathrin-mediated endocytosis. 2GF-GNPs showed no toxic effect on cell cycle and proliferation. Conclusion: These findings promote development of metabolic-based cancer detection technologies, and suggest that 2GF-GNPs may enable specific cancer detection in a wide range of tumors characterized by high GLUT-1 expression.",

keywords = "GLUT-1, cancer, clathrin-mediated endocytosis, glucose-coated nanoparticles, gold nanoparticles, metabolic-Targeting",

author = "Tamar Dreifuss and Ben-Gal, {Tal Shachar} and Katerina Shamalov and Aryeh Weiss and Avi Jacob and Tamar Sadan and Menachem Motiei and Rachela Popovtzer",

note = "Publisher Copyright: {\textcopyright} 2018 2018 Future Medicine Ltd.",

year = "2018",

doi = "https://doi.org/10.2217/nnm-2018-0022",

language = "الإنجليزيّة",

volume = "13",

pages = "1535--1549",

journal = "Nanomedicine",

issn = "1743-5889",

publisher = "Taylor and Francis Ltd.",

number = "13",

}

TY - JOUR

T1 - Uptake mechanism of metabolic-Targeted gold nanoparticles

AU - Dreifuss, Tamar

AU - Ben-Gal, Tal Shachar

AU - Shamalov, Katerina

AU - Weiss, Aryeh

AU - Jacob, Avi

AU - Sadan, Tamar

AU - Motiei, Menachem

AU - Popovtzer, Rachela

PY - 2018

Y1 - 2018

N2 - Aim: To elucidate the interactions, uptake mechanisms and cytotoxicity profile of glucose-functionalized gold nanoparticles (2GF-GNPs), for expanding and advancing the recently proposed technology of metabolic-based cancer detection to a variety of cancer diseases. Methods: Several cell types with different metabolic features were used to assess the involvement of GLUT-1 and different endocytosis pathways in 2GF-GNP uptake, and the cytotoxicity profile of 2GF-GNPs. Results: Cellular uptake of 2GF-GNP strongly correlated with GLUT-1 surface expression, and occurred mainly through clathrin-mediated endocytosis. 2GF-GNPs showed no toxic effect on cell cycle and proliferation. Conclusion: These findings promote development of metabolic-based cancer detection technologies, and suggest that 2GF-GNPs may enable specific cancer detection in a wide range of tumors characterized by high GLUT-1 expression.

AB - Aim: To elucidate the interactions, uptake mechanisms and cytotoxicity profile of glucose-functionalized gold nanoparticles (2GF-GNPs), for expanding and advancing the recently proposed technology of metabolic-based cancer detection to a variety of cancer diseases. Methods: Several cell types with different metabolic features were used to assess the involvement of GLUT-1 and different endocytosis pathways in 2GF-GNP uptake, and the cytotoxicity profile of 2GF-GNPs. Results: Cellular uptake of 2GF-GNP strongly correlated with GLUT-1 surface expression, and occurred mainly through clathrin-mediated endocytosis. 2GF-GNPs showed no toxic effect on cell cycle and proliferation. Conclusion: These findings promote development of metabolic-based cancer detection technologies, and suggest that 2GF-GNPs may enable specific cancer detection in a wide range of tumors characterized by high GLUT-1 expression.

KW - GLUT-1

KW - cancer

KW - clathrin-mediated endocytosis

KW - glucose-coated nanoparticles

KW - gold nanoparticles

KW - metabolic-Targeting

UR - http://www.scopus.com/inward/record.url?scp=85050565299&partnerID=8YFLogxK

U2 - https://doi.org/10.2217/nnm-2018-0022

DO - https://doi.org/10.2217/nnm-2018-0022

M3 - مقالة

C2 - 30028251

SN - 1743-5889

VL - 13

SP - 1535

EP - 1549

JO - Nanomedicine

JF - Nanomedicine

IS - 13

ER -

Uptake mechanism of metabolic-Targeted gold nanoparticles

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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