Unraveling bacterial networks and their antimicrobial susceptibility on silicon microarchitectures using intrinsic phase-shift spectroscopy

Heidi Leonard, Yuri Haimov, Liran Holtzman, Sarel Halachmi, Ofer Nativ, Ester Segal

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

To tackle the bottlenecks of clinical antibiotic susceptibility testing we have designed silicon microstructured arrays to provide a preferable solid-liquid interface for bacterial networking and a simultaneous transducing element that monitors responses of bacteria when exposed to antibiotics in real time. We harness the intrinsic ability of micro-architectures to relay optical phase-shift reflectometric interference spectroscopic measurements (termed PRISM) and employ it as a platform for culture-free, label-free tracking of bacterial accumulation, proliferation, and death.

Original languageEnglish
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Pages38-39
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: 22 Oct 201726 Oct 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Country/TerritoryUnited States
CitySavannah
Period22/10/1726/10/17

Keywords

  • Antimicrobial susceptibility
  • Bacterial resistance
  • Diffraction grating
  • Micropillar

All Science Journal Classification (ASJC) codes

  • Chemical Engineering (miscellaneous)
  • Bioengineering

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