TY - JOUR
T1 - Unlocking the Role of Age-Related Changes to Fibroblasts in Pancreatic Cancer
AU - Isaacson, Achinoam
AU - Barki, Debra
AU - Scherz-Shouval, Ruth
PY - 2024/4/15
Y1 - 2024/4/15
N2 - Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression.
AB - Pancreatic cancer prevalence increases with age, and disease prognosis is poorer in older individuals. The increased prevalence is driven, undoubtedly, by the multistep accumulation of oncogenic mutations in cancer cells with age. However, fibroblasts are major constituents and key players in pancreatic cancer, and they too undergo age-related changes that may contribute to disease severity. In this issue of Cancer Research, Zabransky and colleagues set out to dissect the effect of age-related changes in pancreatic fibroblasts on pancreatic ductal adenocarcinoma growth and metastasis. They discovered that aged fibroblasts secrete GDF-15, which in turn activates AKT signaling and accelerates tumor progression. These findings provide a mechanistic role for aged fibroblasts in pancreatic cancer, underpinning the importance of normal physiologic processes in tumor progression.
UR - http://www.scopus.com/inward/record.url?scp=85190901461&partnerID=8YFLogxK
U2 - https://doi.org/10.1158/0008-5472.CAN-24-0439
DO - https://doi.org/10.1158/0008-5472.CAN-24-0439
M3 - تعليقَ / نقاش
C2 - 38616657
SN - 0008-5472
VL - 84
SP - 1185
EP - 1187
JO - Cancer Research
JF - Cancer Research
IS - 8
ER -