Ultrafast 2D1H-1H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

Kawarpal Singh; Corentin Jacquemmoz; Patrick Giraudeau; Lucio Frydman; Jean-Nicolas Dumez

doi:10.1039/D1CC03079E

Ultrafast 2D¹H-¹H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

Kawarpal Singh, Corentin Jacquemmoz, Patrick Giraudeau, Lucio Frydman, Jean-Nicolas Dumez

Department of Chemical and Biological Physics

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.

Original language	English
Pages (from-to)	8035-8038
Number of pages	4
Journal	Chemical Communications
Volume	57
Issue number	65
DOIs	https://doi.org/10.1039/D1CC03079E
State	Published - 21 Aug 2021

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.",

author = "Kawarpal Singh and Corentin Jacquemmoz and Patrick Giraudeau and Lucio Frydman and Jean-Nicolas Dumez",

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AU - Singh, Kawarpal

AU - Jacquemmoz, Corentin

AU - Giraudeau, Patrick

AU - Frydman, Lucio

AU - Dumez, Jean-Nicolas

PY - 2021/8/21

Y1 - 2021/8/21

N2 - We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.

AB - We show that TOCSY and multiple-quantum (MQ) 2D NMR spectra can be obtained for mixtures of substrates hyperpolarised by dissolution dynamic nuclear polarisation (D-DNP). This is achieved by combining optimised transfer settings for D-DNP, with ultrafast 2D NMR experiments based on spatiotemporal encoding. TOCSY and MQ experiments are particularly well suited for mixture analysis, and this approach opens the way to significant sensitivity gains for analytical applications of NMR, such as authentication and metabolomics.

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U2 - 10.1039/D1CC03079E

DO - 10.1039/D1CC03079E

M3 - مقالة

SN - 1359-7345

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SP - 8035

EP - 8038

JO - Chemical Communications

JF - Chemical Communications

IS - 65

ER -

Ultrafast 2D¹H-¹H NMR spectroscopy of DNP-hyperpolarised substrates for the analysis of mixtures

Abstract

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