Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Rui Zhang; Liang Cheng; Ziliang Dong; Linqian Hou; Shaohua Zhang; Zhouqi Meng; Oshra Betzer; Yihua Wang; Rachela Popovtzer; Zhuang Liu

doi:10.1039/d0mh00193g

Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Rui Zhang
, Liang Cheng
, Ziliang Dong
, Linqian Hou
, Shaohua Zhang
, Zhouqi Meng
, Oshra Betzer
, Yihua Wang
, Rachela Popovtzer
, Zhuang Liu

Bar-Ilan University

Research output: Contribution to journal › Article › peer-review

Abstract

Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

Original language	English
Pages (from-to)	1314-1322
Number of pages	9
Journal	Materials Horizons
Volume	8
Issue number	4
DOIs	https://doi.org/10.1039/d0mh00193g
State	Published - Apr 2021

ASJC Scopus subject areas

Mechanics of Materials
Electrical and Electronic Engineering
Process Chemistry and Technology
General Materials Science

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10.1039/d0mh00193g

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title = "Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief",

abstract = "Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.",

author = "Rui Zhang and Liang Cheng and Ziliang Dong and Linqian Hou and Shaohua Zhang and Zhouqi Meng and Oshra Betzer and Yihua Wang and Rachela Popovtzer and Zhuang Liu",

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year = "2021",

month = apr,

doi = "10.1039/d0mh00193g",

language = "English",

volume = "8",

pages = "1314--1322",

journal = "Materials Horizons",

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TY - JOUR

T1 - Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

AU - Zhang, Rui

AU - Cheng, Liang

AU - Dong, Ziliang

AU - Hou, Linqian

AU - Zhang, Shaohua

AU - Meng, Zhouqi

AU - Betzer, Oshra

AU - Wang, Yihua

AU - Popovtzer, Rachela

AU - Liu, Zhuang

PY - 2021/4

Y1 - 2021/4

N2 - Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

AB - Acute kidney injury (AKI) is frequently associated with reactive oxygen species (ROS) and causes high mortality in clinics annually, and nanotechnology-mediated antioxidative therapy is emerging as a novel strategy for AKI treatment. Herein, four kinds of natural antioxidants are able to coordinate with iron (Fe) ions to form ultra-small coordination polymer nanodots (CPNs) with good water dispersibility and strong ROS scavenging ability. In particular, Fe-curcumin CPNs (Fe-Cur CPNs) are applied for cellular ROS scavenging and rhabdomyolysis-induced AKI relief.

UR - https://www.scopus.com/pages/publications/85104096053

U2 - 10.1039/d0mh00193g

DO - 10.1039/d0mh00193g

M3 - Article

C2 - 34821924

SN - 2051-6347

VL - 8

SP - 1314

EP - 1322

JO - Materials Horizons

JF - Materials Horizons

IS - 4

ER -

Ultra-small natural product based coordination polymer nanodots for acute kidney injury relief

Abstract

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