Ubiquitin Signaling and Degradation of Aggregate-Prone Proteins

Margarita Galves, Ritu Rathi, Gali Prag, Avraham Ashkenazi

Research output: Contribution to journalReview articlepeer-review


Mutant protein aggregation and misfolding is often correlated with toxicity in neurodegenerative diseases. Aggregate-prone proteins are tagged by ubiquitin that signals them for destruction by the proteasome or autophagy, two key pathways for protein degradation and proteostasis. Here, we review recent studies showing that the regulation of aggregate-prone proteins by ubiquitin signaling is more complex than initially postulated. We discuss how the ubiquitin code of aggregate-prone proteins is written by specific E3 ubiquitin ligases and edited by deubiquitylating enzymes (DUBs) in cells and in brain tissues, as well as how this affects protein degradation. These studies have advanced our understanding of the specificity of the ubiquitin system and provide new information about its relevance to neurodegenerative diseases and therapy.

Original languageEnglish
Pages (from-to)872-884
Number of pages13
JournalTrends in Biochemical Sciences
Issue number10
StatePublished - Oct 2019


  • E3 ubiquitin ligase
  • autophagy
  • deubiquitylating enzyme
  • neurodegenerative diseases
  • proteasome

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology


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