Turning off Bacillus cereus quorum sensing system with peptidic analogs

Avishag Yehuda; Leyla Slamti; Racheli Bochnik-Tamir; Einav Malach; Didier Lereclus; Zvi Hayouka

doi:10.1039/c8cc05496g

Turning off Bacillus cereus quorum sensing system with peptidic analogs

Avishag Yehuda, Leyla Slamti, Racheli Bochnik-Tamir, Einav Malach, Didier Lereclus, Zvi Hayouka

Institute of Biochemistry, Food Science and Nutrition

The Hebrew University of Jerusalem

Research output: Contribution to journal › Article › peer-review

Abstract

We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR₇-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

Original language	English
Pages (from-to)	9777-9780
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	70
DOIs	https://doi.org/10.1039/c8cc05496g
State	Published - 2018

All Science Journal Classification (ASJC) codes

Electronic, Optical and Magnetic Materials
Catalysis
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c8cc05496g

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title = "Turning off Bacillus cereus quorum sensing system with peptidic analogs",

abstract = "We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.",

author = "Avishag Yehuda and Leyla Slamti and Racheli Bochnik-Tamir and Einav Malach and Didier Lereclus and Zvi Hayouka",

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T1 - Turning off Bacillus cereus quorum sensing system with peptidic analogs

AU - Yehuda, Avishag

AU - Slamti, Leyla

AU - Bochnik-Tamir, Racheli

AU - Malach, Einav

AU - Lereclus, Didier

AU - Hayouka, Zvi

PY - 2018

Y1 - 2018

N2 - We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

AB - We explored quenching of the PlcR-PapR quorum-sensing system in Bacillus cereus. We generated PapR7-peptidic derivatives that inhibit this system and thus the production of virulence factors, reflected by a loss in hemolytic activity, without affecting bacterial growth. To our knowledge, these peptides represent the first potent synthetic inhibitors of quorum-sensing in B. cereus.

UR - http://www.scopus.com/inward/record.url?scp=85052678020&partnerID=8YFLogxK

U2 - 10.1039/c8cc05496g

DO - 10.1039/c8cc05496g

M3 - مقالة

C2 - 30105347

SN - 1359-7345

VL - 54

SP - 9777

EP - 9780

JO - Chemical Communications

JF - Chemical Communications

IS - 70

ER -

Turning off Bacillus cereus quorum sensing system with peptidic analogs

Abstract

All Science Journal Classification (ASJC) codes

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