Tumor Growth Ameliorates Cardiac Dysfunction

Lama Awwad, Rona Shofti, Tali Haas, Ami Aronheim

Research output: Contribution to journalArticlepeer-review


Heart failure and cancer are the deadliest diseases worldwide. Murine models for cardiac remodeling and heart failure demonstrate that cardiac dysfunction promotes cancer progression and metastasis spread. Yet, no information is available on whether and how tumor progression affects cardiac remodeling. Here, we examined cardiac remodeling following transverse aortic constriction (TAC) in the presence or absence of proliferating cancer cells. We show that tumor-bearing mice, of two different cancer cell lines, display reduced cardiac hypertrophy, lower fibrosis and improved cardiac contractile function following pressure overload induced by TAC surgery. Integrative analysis of qRT-PCR, flow cytometry and immunofluorescence identified tumor-dependent M1-to-M2 polarization in the cardiac macrophage population as a mediator of the beneficial tumor effect on the heart. Importantly, tumor-bearing mice lacking functional macrophages fail to improve cardiac function and display sustained fibrosis.

Original languageEnglish
Article number1853
Issue number14
StatePublished - Jul 2023


  • Animals
  • Fibrosis
  • Heart
  • Heart Failure/metabolism
  • Mice
  • Neoplasms
  • Ventricular Remodeling
  • cardiac fibrosis
  • cardiac hypertrophy
  • heart failure
  • immune system
  • macrophage polarization
  • tumor

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)


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