Tumor environment-specific expression of chimeric antigen receptors

Angel Porgador (Inventor), Roi Gazit (Inventor)

Research output: Patent

Abstract

A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence encoding a synthetic promoter comprising one or more promoter- response-elements, and a nucleic acid sequence encoding immune-effector genes, such as chimeric antigen receptor. The TME responsive vector is designed to induce the expression of immune-effector genes within TME, and not in normal healthy tissues, thus focusing immune activities, increasing safety and reducing the ON-target OFF- tumor hazard.

Original languageAmerican English
Patent numberAU2019221324
IPCC12N 15/ 867 A I
Priority date14/02/19
StatePublished - 3 Sep 2020

Fingerprint

Dive into the research topics of 'Tumor environment-specific expression of chimeric antigen receptors'. Together they form a unique fingerprint.

Cite this