Abstract
A Tumor Micro-Environment (TME) responsive expression vector including a nucleic acid sequence encoding a synthetic promoter comprising one or more promoter- response-elements, and a nucleic acid sequence encoding immune-effector genes, such as chimeric antigen receptor. The TME responsive vector is designed to induce the expression of immune-effector genes within TME, and not in normal healthy tissues, thus focusing immune activities, increasing safety and reducing the ON-target OFF- tumor hazard.
| Original language | American English |
|---|---|
| Patent number | WO2019159173 |
| IPC | C12N 15/ 867 A I |
| Priority date | 23/12/18 |
| State | Published - 22 Aug 2019 |