Trimodal nanoparticle contrast agent for CT, MRI and SPECT imaging: Synthesis and characterization of radiolabeled core/shell iron oxide@gold nanoparticles

Tamar Sadan; Noam Omer; Tamar Blumenfeld-Katzir; Eirini Fragogeorgi; George Loudos; Rachela Popovtzer; Noam Ben-Eliezer

doi:10.1246/cl.180780

Trimodal nanoparticle contrast agent for CT, MRI and SPECT imaging: Synthesis and characterization of radiolabeled core/shell iron oxide@gold nanoparticles

Tamar Sadan, Noam Omer, Tamar Blumenfeld-Katzir, Eirini Fragogeorgi, George Loudos, Rachela Popovtzer, Noam Ben-Eliezer

Bar-Ilan University, Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Recently, nanoparticles have emerged as promising contrast agents for various imaging applications. In this paper, we present the synthesis and characterization of a novel hybrid nano-struc-ture, consisting of an iron oxide@gold nanoparticle, labeled with technetium-99m, for trimodal SPECT/CT/MRI imaging. The particles showed efficient capabilities as CT/MRI imaging agent and high radiochemical yield, indicating a potential single hybrid material for multimodal SPECT/CT/MRI.

Original language	English
Pages (from-to)	291-294
Number of pages	4
Journal	Chemistry Letters
Volume	48
Issue number	3
DOIs	https://doi.org/10.1246/cl.180780
State	Published - 2019

Keywords

Core/shell nanoparticles
Multimodal imaging
Nanoparticle contrast agents

All Science Journal Classification (ASJC) codes

General Chemistry

Access to Document

10.1246/cl.180780

Cite this

@article{a5b77ae12a0d4eaa8c84c843be0e9e74,

title = "Trimodal nanoparticle contrast agent for CT, MRI and SPECT imaging: Synthesis and characterization of radiolabeled core/shell iron oxide@gold nanoparticles",

abstract = "Recently, nanoparticles have emerged as promising contrast agents for various imaging applications. In this paper, we present the synthesis and characterization of a novel hybrid nano-struc-ture, consisting of an iron oxide@gold nanoparticle, labeled with technetium-99m, for trimodal SPECT/CT/MRI imaging. The particles showed efficient capabilities as CT/MRI imaging agent and high radiochemical yield, indicating a potential single hybrid material for multimodal SPECT/CT/MRI.",

keywords = "Core/shell nanoparticles, Multimodal imaging, Nanoparticle contrast agents",

author = "Tamar Sadan and Noam Omer and Tamar Blumenfeld-Katzir and Eirini Fragogeorgi and George Loudos and Rachela Popovtzer and Noam Ben-Eliezer",

note = "Publisher Copyright: {\textcopyright} 2019 The Chemical Society of Japan.",

year = "2019",

doi = "10.1246/cl.180780",

language = "الإنجليزيّة",

volume = "48",

pages = "291--294",

journal = "Chemistry Letters",

issn = "0366-7022",

publisher = "The Chemical Society of Japan",

number = "3",

}

TY - JOUR

T1 - Trimodal nanoparticle contrast agent for CT, MRI and SPECT imaging

T2 - Synthesis and characterization of radiolabeled core/shell iron oxide@gold nanoparticles

AU - Sadan, Tamar

AU - Omer, Noam

AU - Blumenfeld-Katzir, Tamar

AU - Fragogeorgi, Eirini

AU - Loudos, George

AU - Popovtzer, Rachela

AU - Ben-Eliezer, Noam

PY - 2019

Y1 - 2019

N2 - Recently, nanoparticles have emerged as promising contrast agents for various imaging applications. In this paper, we present the synthesis and characterization of a novel hybrid nano-struc-ture, consisting of an iron oxide@gold nanoparticle, labeled with technetium-99m, for trimodal SPECT/CT/MRI imaging. The particles showed efficient capabilities as CT/MRI imaging agent and high radiochemical yield, indicating a potential single hybrid material for multimodal SPECT/CT/MRI.

AB - Recently, nanoparticles have emerged as promising contrast agents for various imaging applications. In this paper, we present the synthesis and characterization of a novel hybrid nano-struc-ture, consisting of an iron oxide@gold nanoparticle, labeled with technetium-99m, for trimodal SPECT/CT/MRI imaging. The particles showed efficient capabilities as CT/MRI imaging agent and high radiochemical yield, indicating a potential single hybrid material for multimodal SPECT/CT/MRI.

KW - Core/shell nanoparticles

KW - Multimodal imaging

KW - Nanoparticle contrast agents

UR - http://www.scopus.com/inward/record.url?scp=85062369767&partnerID=8YFLogxK

U2 - 10.1246/cl.180780

DO - 10.1246/cl.180780

M3 - مقالة

SN - 0366-7022

VL - 48

SP - 291

EP - 294

JO - Chemistry Letters

JF - Chemistry Letters

IS - 3

ER -

Trimodal nanoparticle contrast agent for CT, MRI and SPECT imaging: Synthesis and characterization of radiolabeled core/shell iron oxide@gold nanoparticles

Abstract

Keywords

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this