Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

Zhixin Zhou; Daoqing Fan; Jianbang Wang; Yang Sung Sohn; Rachel Nechushtai; Itamar Willner

doi:https://doi.org/10.1002/smll.202007355

Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

Zhixin Zhou, Daoqing Fan, Jianbang Wang, Yang Sung Sohn, Rachel Nechushtai, Itamar Willner

The Hebrew University of Jerusalem

Research output: Contribution to journal › Review article › peer-review

Abstract

The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K⁺-ion-stabilized G-quadruplexes or T-A•T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal-triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA-sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.

Original language	English
Article number	2007355
Journal	Small
Volume	17
Issue number	6
DOIs	https://doi.org/10.1002/smll.202007355
State	Published - 11 Feb 2021

Keywords

DNA nanotechnology
G-quadruplexes
fluorescence
logic gates
sensors
triplexes

All Science Journal Classification (ASJC) codes

General Chemistry
Engineering (miscellaneous)
Biotechnology
General Materials Science
Biomaterials

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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https://doi.org/10.1002/smll.202007355

Cite this

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title = "Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells",

abstract = "The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K+-ion-stabilized G-quadruplexes or T-A•T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal-triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA-sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.",

keywords = "DNA nanotechnology, G-quadruplexes, fluorescence, logic gates, sensors, triplexes",

author = "Zhixin Zhou and Daoqing Fan and Jianbang Wang and Sohn, {Yang Sung} and Rachel Nechushtai and Itamar Willner",

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doi = "https://doi.org/10.1002/smll.202007355",

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TY - JOUR

T1 - Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

AU - Zhou, Zhixin

AU - Fan, Daoqing

AU - Wang, Jianbang

AU - Sohn, Yang Sung

AU - Nechushtai, Rachel

AU - Willner, Itamar

PY - 2021/2/11

Y1 - 2021/2/11

N2 - The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K+-ion-stabilized G-quadruplexes or T-A•T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal-triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA-sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.

AB - The reversible and switchable triggered reconfiguration of tetrahedra nanostructures from monomer tetrahedra structures into dimer or trimer structures is introduced. The triggered bridging of monomer tetrahedra by K+-ion-stabilized G-quadruplexes or T-A•T triplexes leads to dimer or trimer tetrahedra structures that are separated by crown ether or basic pH conditions, respectively. The signal-triggered dimerization/trimerization of DNA tetrahedra structures is used to develop multiplexed miRNA-sensing platforms, and the tetrahedra mixture is used for intracellular sensing and imaging of miRNAs.

KW - DNA nanotechnology

KW - G-quadruplexes

KW - fluorescence

KW - logic gates

KW - sensors

KW - triplexes

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U2 - https://doi.org/10.1002/smll.202007355

DO - https://doi.org/10.1002/smll.202007355

M3 - مقالة مرجعية

C2 - 33470517

SN - 1613-6810

VL - 17

JO - Small

JF - Small

IS - 6

M1 - 2007355

ER -

Triggered Dimerization and Trimerization of DNA Tetrahedra for Multiplexed miRNA Detection and Imaging of Cancer Cells

Abstract

Keywords

All Science Journal Classification (ASJC) codes

UN SDGs

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