Triazole-resistant aspergillus fumigatus in an Israeli patient with chronic cavitary pulmonary aspergillosis due to a novel E306K substitution in Hmg1

Mariana Handelman; Alma Morogovsky; Wei Liu; Ronen Ben-Ami; Nir Osherov

doi:10.1128/AAC.01089-21

Triazole-resistant aspergillus fumigatus in an Israeli patient with chronic cavitary pulmonary aspergillosis due to a novel E306K substitution in Hmg1

Mariana Handelman, Alma Morogovsky, Wei Liu, Ronen Ben-Ami, Nir Osherov

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

Abstract

Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide, posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been associated with triazole resistance. Here, we describe a novel E306K triazole resistance-conferring mutation in the HMG-CoA reductase gene from an Israeli patient with chronic cavitary pulmonary aspergillosis (CCPA).

Original language	English
Article number	e01089-21
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	10
DOIs	https://doi.org/10.1128/AAC.01089-21
State	Published - Oct 2021

Keywords

Antifungal resistance
Aspergillus fumigatus
Azole resistance
E306K substitution
HMG1 mutations
Hmg1 resistance mutation
Mycology
Triazole resistance

All Science Journal Classification (ASJC) codes

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Triazole-resistant aspergillus fumigatus in an Israeli patient with chronic cavitary pulmonary aspergillosis due to a novel E306K substitution in Hmg1",

abstract = "Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide, posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been associated with triazole resistance. Here, we describe a novel E306K triazole resistance-conferring mutation in the HMG-CoA reductase gene from an Israeli patient with chronic cavitary pulmonary aspergillosis (CCPA).",

keywords = "Antifungal resistance, Aspergillus fumigatus, Azole resistance, E306K substitution, HMG1 mutations, Hmg1 resistance mutation, Mycology, Triazole resistance",

author = "Mariana Handelman and Alma Morogovsky and Wei Liu and Ronen Ben-Ami and Nir Osherov",

year = "2021",

month = oct,

doi = "10.1128/AAC.01089-21",

language = "الإنجليزيّة",

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TY - JOUR

T1 - Triazole-resistant aspergillus fumigatus in an Israeli patient with chronic cavitary pulmonary aspergillosis due to a novel E306K substitution in Hmg1

AU - Handelman, Mariana

AU - Morogovsky, Alma

AU - Liu, Wei

AU - Ben-Ami, Ronen

AU - Osherov, Nir

PY - 2021/10

Y1 - 2021/10

N2 - Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide, posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been associated with triazole resistance. Here, we describe a novel E306K triazole resistance-conferring mutation in the HMG-CoA reductase gene from an Israeli patient with chronic cavitary pulmonary aspergillosis (CCPA).

AB - Triazole resistance in the pathogenic mold Aspergillus fumigatus has increased worldwide, posing a growing therapeutic challenge. Recently, mutations in the 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase gene (hmg1) have been associated with triazole resistance. Here, we describe a novel E306K triazole resistance-conferring mutation in the HMG-CoA reductase gene from an Israeli patient with chronic cavitary pulmonary aspergillosis (CCPA).

KW - Antifungal resistance

KW - Aspergillus fumigatus

KW - Azole resistance

KW - E306K substitution

KW - HMG1 mutations

KW - Hmg1 resistance mutation

KW - Mycology

KW - Triazole resistance

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U2 - 10.1128/AAC.01089-21

DO - 10.1128/AAC.01089-21

M3 - مقالة

C2 - 34280014

SN - 0066-4804

VL - 65

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 10

M1 - e01089-21

ER -

Triazole-resistant aspergillus fumigatus in an Israeli patient with chronic cavitary pulmonary aspergillosis due to a novel E306K substitution in Hmg1

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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