TRF2: TRansForming the view of general transcription factors

Yonathan Zehavi; Adi Kedmi; Diana Ideses; Tamar Juven-Gershon

doi:https://doi.org/10.1080/21541264.2015.1004980

TRF2: TRansForming the view of general transcription factors

Yonathan Zehavi, Adi Kedmi, Diana Ideses, Tamar Juven-Gershon

The Mina and Everard Goodman Faculty of Life Sciences

Bar-Ilan University

Research output: Contribution to journal › Review article › peer-review

Abstract

Abstract: Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.

Original language	English
Journal	Transcription
Volume	6
Issue number	1
DOIs	https://doi.org/10.1080/21541264.2015.1004980
State	Published - 1 Jan 2015

Keywords

DPE
RNA Pol II transcription
TBP-related factors
TCT
TRF2
core promoter elements/motifs
embryonic development
histone gene cluster
ribosomal protein genes
spermiogenesis

All Science Journal Classification (ASJC) codes

Biotechnology
Biochemistry
Genetics

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https://doi.org/10.1080/21541264.2015.1004980

Cite this

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title = "TRF2: TRansForming the view of general transcription factors",

abstract = "Abstract: Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.",

keywords = "DPE, RNA Pol II transcription, TBP-related factors, TCT, TRF2, core promoter elements/motifs, embryonic development, histone gene cluster, ribosomal protein genes, spermiogenesis",

author = "Yonathan Zehavi and Adi Kedmi and Diana Ideses and Tamar Juven-Gershon",

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AU - Zehavi, Yonathan

AU - Kedmi, Adi

AU - Ideses, Diana

AU - Juven-Gershon, Tamar

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Abstract: Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.

AB - Abstract: Transcriptional regulation is pivotal for development and differentiation of organisms. Transcription of eukaryotic protein-coding genes by RNA polymerase II (Pol II) initiates at the core promoter. Core promoters, which encompass the transcription start site, may contain functional core promoter elements, such as the TATA box, initiator, TCT and downstream core promoter element. TRF2 (TATA-box-binding protein-related factor 2) does not bind TATA box-containing promoters. Rather, it is recruited to core promoters via sequences other than the TATA box. We review the recent findings implicating TRF2 as a basal transcription factor in the regulation of diverse biological processes and specialized transcriptional programs.

KW - DPE

KW - RNA Pol II transcription

KW - TBP-related factors

KW - TCT

KW - TRF2

KW - core promoter elements/motifs

KW - embryonic development

KW - histone gene cluster

KW - ribosomal protein genes

KW - spermiogenesis

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DO - https://doi.org/10.1080/21541264.2015.1004980

M3 - مقالة مرجعية

C2 - 25588059

SN - 2154-1264

VL - 6

JO - Transcription

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TRF2: TRansForming the view of general transcription factors

Abstract

Keywords

All Science Journal Classification (ASJC) codes

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