Transverse relaxation of selectively excited metabolites in stroke at 21.1T

Jens T. Rosenberg; Noam Shemesh; Jose A. Muniz; Jean-Nicolas Dumez; Lucio Frydman; Samuel C. Grant

doi:10.1002/mrm.26132

Transverse relaxation of selectively excited metabolites in stroke at 21.1T

Jens T. Rosenberg, Noam Shemesh, Jose A. Muniz, Jean-Nicolas Dumez, Lucio Frydman, Samuel C. Grant

Department of Chemical and Biological Physics

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: This study seeks to evaluate in vivo T-2 relaxation times of selectively excited stroke-relevant metabolites via H-1 relaxation-enhanced magnetic resonance spectroscopy (RE-MRS) at 21.1T (900 MHz).

Methods: A quadrature surface coil was designed and optimized for investigations of rodents at 21.1T. With voxel localization, a RE-MRS pulse sequence incorporating the excitation of selected metabolites was modified to include a variable echo delay for T-2 measurements. A middle cerebral artery occlusion (MCAO) animal model for stroke was examined with spectra taken 24h post occlusion. Fourteen echo times were acquired, with each measurement completed in less than 2min.

Results: The RE-MRS approach produced high-quality spectra of the selectively excited metabolites in the stroked and contralateral regions. T-2 measurements reveal differential results between these regions, with significance achieved for lactic acid.

Conclusion: Using the RE-MRS technique at ultra-high magnetic field and an optimized quadrature surface coil design, full metabolic T-2 quantifications in a localized voxel is now possible in less than 27min. Magn Reson Med 77:520-528, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine

Original language	English
Pages (from-to)	520-528
Number of pages	9
Journal	Magnetic Resonance in Medicine
Volume	77
Issue number	2
DOIs	https://doi.org/10.1002/mrm.26132
State	Published - Feb 2017

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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@article{ae213a79b3714189b67ed13e7c0272ab,

title = "Transverse relaxation of selectively excited metabolites in stroke at 21.1T",

abstract = "Purpose: This study seeks to evaluate in vivo T-2 relaxation times of selectively excited stroke-relevant metabolites via H-1 relaxation-enhanced magnetic resonance spectroscopy (RE-MRS) at 21.1T (900 MHz).Methods: A quadrature surface coil was designed and optimized for investigations of rodents at 21.1T. With voxel localization, a RE-MRS pulse sequence incorporating the excitation of selected metabolites was modified to include a variable echo delay for T-2 measurements. A middle cerebral artery occlusion (MCAO) animal model for stroke was examined with spectra taken 24h post occlusion. Fourteen echo times were acquired, with each measurement completed in less than 2min.Results: The RE-MRS approach produced high-quality spectra of the selectively excited metabolites in the stroked and contralateral regions. T-2 measurements reveal differential results between these regions, with significance achieved for lactic acid.Conclusion: Using the RE-MRS technique at ultra-high magnetic field and an optimized quadrature surface coil design, full metabolic T-2 quantifications in a localized voxel is now possible in less than 27min. Magn Reson Med 77:520-528, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine",

author = "Rosenberg, {Jens T.} and Noam Shemesh and Muniz, {Jose A.} and Jean-Nicolas Dumez and Lucio Frydman and Grant, {Samuel C.}",

note = "NSF [DMR-1157490]; State of Florida; NHMFL; American Heart Association [10GRNT3860040]; Israel Science Foundation [ISF 795/13, 1142/13]; Kimmel Institute for Magnetic Resonance; Perlman Family Foundation; [NHMFL 12601] The authors would like to thank Ashley Blue and Fabian Calixto Bejarano for technical assistance. This work was performed at the National High Magnetic Field Laboratory, which is supported by NSF DMR-1157490 and the State of Florida. Funding was also provided by the NHMFL User Collaboration Grants Program (to SGC) and the American Heart Association Grant-in-Aid program (10GRNT3860040). The authors also wish to thank the Israel Science Foundation (Grants ISF 795/13 and 1142/13), the Kimmel Institute for Magnetic Resonance, and the generosity of the Perlman Family Foundation (to LF). NS acknowledges a Visiting Scientist Program grant (NHMFL 12601). LF and SCG contributed equally to this study.",

year = "2017",

month = feb,

doi = "10.1002/mrm.26132",

language = "الإنجليزيّة",

volume = "77",

pages = "520--528",

journal = "Magnetic Resonance in Medicine",

issn = "0740-3194",

publisher = "John Wiley and Sons Inc.",

number = "2",

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T1 - Transverse relaxation of selectively excited metabolites in stroke at 21.1T

AU - Rosenberg, Jens T.

AU - Shemesh, Noam

AU - Muniz, Jose A.

AU - Dumez, Jean-Nicolas

AU - Frydman, Lucio

AU - Grant, Samuel C.

N1 - NSF [DMR-1157490]; State of Florida; NHMFL; American Heart Association [10GRNT3860040]; Israel Science Foundation [ISF 795/13, 1142/13]; Kimmel Institute for Magnetic Resonance; Perlman Family Foundation; [NHMFL 12601] The authors would like to thank Ashley Blue and Fabian Calixto Bejarano for technical assistance. This work was performed at the National High Magnetic Field Laboratory, which is supported by NSF DMR-1157490 and the State of Florida. Funding was also provided by the NHMFL User Collaboration Grants Program (to SGC) and the American Heart Association Grant-in-Aid program (10GRNT3860040). The authors also wish to thank the Israel Science Foundation (Grants ISF 795/13 and 1142/13), the Kimmel Institute for Magnetic Resonance, and the generosity of the Perlman Family Foundation (to LF). NS acknowledges a Visiting Scientist Program grant (NHMFL 12601). LF and SCG contributed equally to this study.

PY - 2017/2

Y1 - 2017/2

N2 - Purpose: This study seeks to evaluate in vivo T-2 relaxation times of selectively excited stroke-relevant metabolites via H-1 relaxation-enhanced magnetic resonance spectroscopy (RE-MRS) at 21.1T (900 MHz).Methods: A quadrature surface coil was designed and optimized for investigations of rodents at 21.1T. With voxel localization, a RE-MRS pulse sequence incorporating the excitation of selected metabolites was modified to include a variable echo delay for T-2 measurements. A middle cerebral artery occlusion (MCAO) animal model for stroke was examined with spectra taken 24h post occlusion. Fourteen echo times were acquired, with each measurement completed in less than 2min.Results: The RE-MRS approach produced high-quality spectra of the selectively excited metabolites in the stroked and contralateral regions. T-2 measurements reveal differential results between these regions, with significance achieved for lactic acid.Conclusion: Using the RE-MRS technique at ultra-high magnetic field and an optimized quadrature surface coil design, full metabolic T-2 quantifications in a localized voxel is now possible in less than 27min. Magn Reson Med 77:520-528, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine

AB - Purpose: This study seeks to evaluate in vivo T-2 relaxation times of selectively excited stroke-relevant metabolites via H-1 relaxation-enhanced magnetic resonance spectroscopy (RE-MRS) at 21.1T (900 MHz).Methods: A quadrature surface coil was designed and optimized for investigations of rodents at 21.1T. With voxel localization, a RE-MRS pulse sequence incorporating the excitation of selected metabolites was modified to include a variable echo delay for T-2 measurements. A middle cerebral artery occlusion (MCAO) animal model for stroke was examined with spectra taken 24h post occlusion. Fourteen echo times were acquired, with each measurement completed in less than 2min.Results: The RE-MRS approach produced high-quality spectra of the selectively excited metabolites in the stroked and contralateral regions. T-2 measurements reveal differential results between these regions, with significance achieved for lactic acid.Conclusion: Using the RE-MRS technique at ultra-high magnetic field and an optimized quadrature surface coil design, full metabolic T-2 quantifications in a localized voxel is now possible in less than 27min. Magn Reson Med 77:520-528, 2017. (c) 2016 International Society for Magnetic Resonance in Medicine

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U2 - 10.1002/mrm.26132

DO - 10.1002/mrm.26132

M3 - مقالة

SN - 0740-3194

VL - 77

SP - 520

EP - 528

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

IS - 2

ER -

Transverse relaxation of selectively excited metabolites in stroke at 21.1T

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